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Drug discovery, development and registration is an expensive and time-consuming process associated with a high failure rate… Expand Significance The identification of new antibiotics with novel mechanisms of action has become a pressing need considering the… Expand Schistosomiasis is a parasitic disease affecting over 200 million people currently treated with one drug, praziquantel. A… Expand Cisplatin is an effective antitumor agent for the treatment of several carcinomas. However, the development of resistance to… Expand Antirheumatic gold compounds have been shown to inhibit NF-κB activation by blocking IκB kinase (IKK) activity. To examine the… Expand Gold(I)‐thiolate drugs are compounds that specifically interact with thiol and/or selenol groups and are essentially utilized in… Expand In a six-month, randomized, double-blind study at 14 centers, auranofin (3 mg twice daily) was compared with placebo in the… Expand The coordinated gold compound, 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosato-S-triethyl phosphine gold (auranofin; Ridaura… Expand Eight patients with rheumatoid arthritis were treated with SK & F D-39162 (auranofin), a new oral gold compound which was… Expand