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Auranofin

Known as: (1-Thio-beta-D-glucopyranosato)(triethylphosphine)gold 2,3,4,6-tetraacetate, 2,3,4,6-Tetra-O-acetyl-1-thio-beta-D-glucopyranosato-S (triethylphosphine)gold, Auranofin [Chemical/Ingredient] 
An orally available, lipophilic, organogold compound, used to treat rheumatoid arthritis, with anti-inflammatory and potential antineoplastic… Expand
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Drug discovery, development and registration is an expensive and time-consuming process associated with a high failure rate… Expand
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Highly Cited
2015
Highly Cited
2015
Significance The identification of new antibiotics with novel mechanisms of action has become a pressing need considering the… Expand
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Highly Cited
2009
Highly Cited
2009
Schistosomiasis is a parasitic disease affecting over 200 million people currently treated with one drug, praziquantel. A… Expand
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Highly Cited
2007
Highly Cited
2007
Cisplatin is an effective antitumor agent for the treatment of several carcinomas. However, the development of resistance to… Expand
Highly Cited
2003
Highly Cited
2003
Antirheumatic gold compounds have been shown to inhibit NF-κB activation by blocking IκB kinase (IKK) activity. To examine the… Expand
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Highly Cited
2002
Highly Cited
2002
Gold(I)‐thiolate drugs are compounds that specifically interact with thiol and/or selenol groups and are essentially utilized in… Expand
Highly Cited
1986
Highly Cited
1986
In a six-month, randomized, double-blind study at 14 centers, auranofin (3 mg twice daily) was compared with placebo in the… Expand
Highly Cited
1985
Highly Cited
1985
The coordinated gold compound, 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosato-S-triethyl phosphine gold (auranofin; Ridaura… Expand
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Highly Cited
1976
Highly Cited
1976
Eight patients with rheumatoid arthritis were treated with SK & F D-39162 (auranofin), a new oral gold compound which was… Expand