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Argininosuccinate Synthase, human

Known as: Argininosuccinate Synthase, Argininosuccinate Synthetase 1, Argininosuccinate Synthetase 
Argininosuccinate synthase (412 aa, ~47 kDa) is encoded by the human ASS1 gene. This protein is involved in the biosynthesis of arginine.
National Institutes of Health

Papers overview

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Review
2007
Review
2007
  • M. Mori
  • The Journal of nutrition
  • 2007
  • Corpus ID: 13676997
Nitric oxide (NO) is synthesized from arginine and O2 by NO synthase (NOS). Citrulline formed as a by-product of the NOS reaction… Expand
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Highly Cited
2007
Highly Cited
2007
Hepatocellular carcinoma (HCC) is believed to be auxotrophic for arginine through the lack of expression of argininosuccinate… Expand
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Highly Cited
2007
Highly Cited
2007
Recently, pegylated arginine deiminase (ADI; EC 3.5.3.6) has been used to treat the patients with hepatocellular carcinoma or… Expand
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Highly Cited
2004
Highly Cited
2004
Argininosuccinate synthetase (ASS) was the first of two enzymes to convert citrulline to arginine. This pathway allowed cells to… Expand
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Highly Cited
2002
Highly Cited
2002
Some murine melanomas and hepatocellular carcinomas (HCCs) have been shown to be auxotrophic for arginine. Arginine deiminase… Expand
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Review
2001
Review
2001
The biochemistry and physiology of L-arginine have to be reconsidered in the light of the recent discovery that the amino acid is… Expand
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Highly Cited
2001
Highly Cited
2001
The enzyme argininosuccinate synthetase (ASS) is the rate limiting enzyme in the metabolic pathway leading from L-citrulline to L… Expand
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Review
2000
Review
2000
  • M. Mori, T. Gotoh
  • Biochemical and biophysical research…
  • 2000
  • Corpus ID: 29548790
Nitric oxide (NO) is synthesized from arginine by NO synthase (NOS), and the availability of arginine is one of the rate-limiting… Expand
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Highly Cited
1994
Highly Cited
1994
In macrophages and other cell types, bacterial lipopolysaccharide and certain cytokines stimulate nitric oxide (NO) production… Expand
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Highly Cited
1986
Highly Cited
1986
Intercellular gap-junctional communication was measured using metabolic co-operation in co-cultures of argininosuccinate… Expand
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