Argininosuccinate Synthase, human

Known as: Argininosuccinate Synthase, Argininosuccinate Synthetase 1, Argininosuccinate Synthetase 
Argininosuccinate synthase (412 aa, ~47 kDa) is encoded by the human ASS1 gene. This protein is involved in the biosynthesis of arginine.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Arginine deprivation, either by nutritional starvation or exposure to ADI-PEG20, induces adaptive transcriptional upregulation of… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Hepatocellular carcinoma (HCC) is believed to be auxotrophic for arginine through the lack of expression of argininosuccinate… (More)
  • figure 1
  • figure 2
  • table 1
  • table 2
  • figure 3
Is this relevant?
Highly Cited
2006
Highly Cited
2006
PURPOSE Malignant pleural mesothelioma (MPM) is an increasing health burden on many societies worldwide and, being generally… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • table 2
Is this relevant?
Review
2006
Review
2006
Pegylated arginine deiminase (ADI-PEG20) is a novel anticancer enzyme that produces depletion of arginine, which is a… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
BACKGROUND Argininosuccinate synthetase (ASS) was the first of two enzymes to convert citrulline to arginine. This pathway… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Some murine melanomas and hepatocellular carcinomas (HCCs) have been shown to be auxotrophic for arginine. Arginine deiminase… (More)
  • table 1
  • table 2
  • figure 1
  • figure 2
  • figure 4
Is this relevant?
Highly Cited
2001
Highly Cited
2001
The enzyme argininosuccinate synthetase (ASS) is the rate limiting enzyme in the metabolic pathway leading from L-citrulline to L… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2001
2001
Although normal intracellular levels of arginine are well above the K(m), and should be sufficient to saturate nitric oxide… (More)
Is this relevant?
1996
1996
Nitric oxide (NO) is synthesized from arginine by nitric oxide synthase (NOS), and citrulline which is generated can be recycled… (More)
Is this relevant?
Highly Cited
1986
Highly Cited
1986
Intercellular gap-junctional communication was measured using metabolic co-operation in co-cultures of argininosuccinate… (More)
Is this relevant?