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Arginine-tRNA Ligase

Known as: Arginyl T RNA Synthetase, Arg-tRNA Ligase, Arginyl tRNA Synthetase 
An enzyme that activates arginine with its specific transfer RNA. EC 6.1.1.19.
National Institutes of Health

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Related topics

9 relations
In BloodProcess of secretionRARS geneRARS2 gene
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Papers overview

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2011
2011
Impairment of the tRNA-splicing endonuclease subunit 54 (tsen54) gene causes neurological abnormalities and larval death in zebrafish models of pontocerebellar hypoplasia.
Pontocerebellar hypoplasia (PCH) represents a group (PCH1-6) of neurodegenerative autosomal recessive disorders characterized by… Expand
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2011
2011
Further delineation of pontocerebellar hypoplasia type 6 due to mutations in the gene encoding mitochondrial arginyl-tRNA synthetase, RARS2
Pontocerebellar hypoplasia type 6 (PCH6) (MIM #611523) is a recently described disorder caused by mutations in RARS2 (MIM *611524… Expand
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Highly Cited
2006
Highly Cited
2006
The La protein functions redundantly with tRNA modification enzymes to ensure tRNA structural stability.
Although the La protein stabilizes nascent pre-tRNAs from nucleases, influences the pathway of pre-tRNA maturation, and assists… Expand
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Review
2006
Review
2006
Role of non-protein amino acid L-canavanine in autoimmunity.
Association of SLE and alfalfa was first reported in a volunteer who developed lupus-like autoimmunity while ingesting alfalfa… Expand
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2005
2005
Determinants in tRNA for activation of arginyl-tRNA synthetase: evidence that tRNA flexibility is required for the induced-fit mechanism.
Arginyl-tRNA synthetase (ArgRS) catalyzes formation of arginyl-adenylate in a tRNA-dependent reaction. Previous studies have… Expand
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Review
2003
Review
2003
The Mechanism of l-Canavanine Cytotoxicity: Arginyl tRNA Synthetase as a Novel Target for Anticancer Drug Discovery
  • A. Bence, P. Crooks
  • Journal of enzyme inhibition and medicinal…
  • 2003
    • Corpus ID: 21127184
There is a clear need for agents with novel mechanisms of action to provide new therapeutic approaches for the treatment of… Expand
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Highly Cited
2000
Highly Cited
2000
tRNA aminoacylation by arginyl‐tRNA synthetase: induced conformations during substrates binding
The 2.2 Å crystal structure of a ternary complex formed by yeast arginyl‐tRNA synthetase and its cognate tRNAArg in the presence… Expand
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Highly Cited
1998
Highly Cited
1998
L‐Arginine recognition by yeast arginyl‐tRNA synthetase
The crystal structure of arginyl‐tRNA synthetase (ArgRS) from Saccharomyces cerevisiae, a class I aminoacyl‐tRNA synthetase (aaRS… Expand
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1990
1990
Existence of two forms of rat liver arginyl-tRNA synthetase suggests channeling of aminoacyl-tRNA for protein synthesis.
Arginyl-tRNA synthetase (arginine-tRNA ligase, EC 6.1.1.19) is found in extracts of mammalian cells both as a free protein (Mr… Expand
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1986
1986
L-Canavanine and protein synthesis in the tobacco hornworm Manduca sexta.
L-Canavanine, a nonprotein amino acid of certain leguminous plants, manifests potent insecticidal properties in a canavanine… Expand
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