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Apoptosis Inducing Factor

Known as: AIF Apoptosis Regulatory Protein, Mitochondrial Apoptosis-Inducing Factor, Apoptosis-Inducing Factor, Mitochondrial 
A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian… Expand
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
The translocation of apoptosis-inducing factor (AIF) from mitochondria to the nucleus has been implicated in the mechanism of… Expand
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Highly Cited
2003
Highly Cited
2003
Mitochondrial dysfunction has been shown to participate in the induction of apoptosis and has even been suggested to be central… Expand
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Highly Cited
2002
Highly Cited
2002
Poly(ADP-ribose) polymerase-1 (PARP-1) protects the genome by functioning in the DNA damage surveillance network. PARP-1 is also… Expand
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Highly Cited
2002
Highly Cited
2002
Caspase-2 is one of the earliest identified caspases, but the mechanism of caspase-2-induced apoptosis remains unknown. We show… Expand
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Highly Cited
2001
Highly Cited
2001
Heat-shock protein 70 (Hsp70) has been reported to block apoptosis by binding apoptosis protease activating factor-1 (Apaf-1… Expand
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Highly Cited
2001
Highly Cited
2001
Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein, which translocates to the nucleus during apoptosis and causes… Expand
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Highly Cited
2000
Highly Cited
2000
Apaf-1−/− or caspase-3−/− cells treated with a variety of apoptosis inducers manifest apoptosis-associated alterations including… Expand
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Highly Cited
2000
Highly Cited
2000
  • Kannan, Jain
  • Pathophysiology : the official journal of the…
  • 2000
  • Corpus ID: 46484993
Apoptosis or programmed cell death, is essential for the normal functioning and survival of most multi-cellular organisms. The… Expand
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Highly Cited
1999
Highly Cited
1999
Mitochondria play a key part in the regulation of apoptosis (cell death). Their intermembrane space contains several proteins… Expand
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Review
1999
Review
1999
Although much emphasis has been laid on the role of caspase in cell death, recent data indicate that, in many instances… Expand
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