Apolipoprotein E2

Known as: APOE epsilon 2, APOE epsilon2, Apolipoprotein E-epsilon2 
One of three major isoforms of apolipoprotein E. In humans, Apo E2 differs from APOLIPOPROTEIN E3 at one residue 158 where arginine is replaced by… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1967-2018
020406019672018

Papers overview

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Highly Cited
2012
Highly Cited
2012
While a potential causal factor in Alzheimer's disease (AD), brain insulin resistance has not been demonstrated directly in that… (More)
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Highly Cited
2009
Highly Cited
2009
Apolipoprotein (apo) E has roles beyond lipoprotein metabolism. The detrimental effects of apoE4 in cardiovascular, neurological… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Diabetes and the apolipoprotein E epsilon4 allele (APOE epsilon4) increase the risk for Alzheimer disease (AD). We… (More)
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Highly Cited
2007
Highly Cited
2007
Genome-wide linkage studies have defined a broad susceptibility region for late-onset Alzheimer's disease on chromosome 12, which… (More)
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Highly Cited
2007
Highly Cited
2007
OBJECTIVE Naturally occurring CD4+ CD25+ regulatory T cells (Tregs) exert suppressive effects on effector CD4 cells and… (More)
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Highly Cited
2005
Highly Cited
2005
Age-related macular degeneration (AMD) is a late-onset, multifactorial, neurodegenerative disease of the retina and the leading… (More)
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Highly Cited
2003
Highly Cited
2003
Postmortem AD brains exhibit dendritic spine loss in the hippocampus. To determine whether this pathology may be associated with… (More)
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Highly Cited
1999
Highly Cited
1999
We quantified the amount of amyloid beta-peptide (Abeta) immunoreactivity as well as amyloid deposits in a large cohort of… (More)
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Highly Cited
1998
Highly Cited
1998
Apolipoprotein E (apoE) mediates the redistribution of lipids among cells and is expressed at highest levels in brain and liver… (More)
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Highly Cited
1996
Highly Cited
1996
The presence of apolipoprotein E-epsilon4 (APOE-epsilon4) allele has been implicated as a risk factor for Alzheimer's disease (AD… (More)
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