Skip to search form
Skip to main content
Skip to account menu
Semantic Scholar
Semantic Scholar's Logo
Search 222,883,064 papers from all fields of science
Search
Sign In
Create Free Account
Apatorsen
A second-generation antisense oligonucleotide targeting heat shock protein 27 (Hsp27) with potential antitumor and chemosensitizing activities…
Expand
National Institutes of Health
Create Alert
Alert
Related topics
Related topics
1 relation
Narrower (1)
OGX-427
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Efficacy and Safety of Chemotherapy Regimens in Advanced or Metastatic Bladder and Urothelial Carcinomas: An Updated Network Meta-Analysis
Hong-Chen Qu
,
Y. Huang
,
+4 authors
Bin Hu
Frontiers in Pharmacology
2020
Corpus ID: 210172947
Background: Gemcitabine plus cisplatin (GC) and methotrexate, vinblastine, adriamycin, and cisplatin (MVAC) have been the first…
Expand
2018
2018
Heat shock protein 27 knockdown using nucleotide ‐ based therapies enhances sensitivity to 5 ‐ FU chemotherapy in SW 480 human colon cancer cells
Takehiro Shimada
,
M. Tsuruta
,
+8 authors
Y. Kitagawa
2018
Corpus ID: 131763115
Heat shock protein 27 (Hsp27) is a chaperone protein of low molecular weight that is produced in response to various stresses and…
Expand
2017
2017
PACIFIC trial: A randomized phase II study of apatorsen and abiraterone in patients (Pts) with metastatic castration-resistant prostate cancer (mCRPC) who have had PSA progression while receiving…
K. Chi
,
M. Fleming
,
+10 authors
C. Sweeney
2017
Corpus ID: 78433207
146Background: Heat Shock Protein 27 (Hsp27) is a multi-functional chaperone that regulates cell signaling and survival pathways…
Expand
2017
2017
Clinical Trials in Pancreatic Cancer: A Long Slog
T. Enzler
,
S. Bates
The Oncologist
2017
Corpus ID: 35136348
Many investigators have turned their efforts toward improving the gemcitabine/nab‐paclitaxel combination by the addition of a…
Expand
2016
2016
Abstract 3759: Inhibition of heat shock protein 27 (Hsp27) expression by apatorsen as a therapeutic strategy in breast cancer
E. Komulainen
,
A. Shia
,
+4 authors
P. Schmid
2016
Corpus ID: 79427382
Background: Heat shock protein 27 (Hsp27) is over-expressed in a number of cancers, including breast cancer, and interacts with…
Expand
2016
2016
The Spruce clinical trial: Double-blind randomized phase II trial of carboplatin and pemetrexed +/- apatorsen in patients with previously untreated stage IV non-squamous non-small-cell lung cancer.
D. Shipley
,
D. Waterhouse
,
+13 authors
D. Spigel
2016
Corpus ID: 81621860
9092Background: Hsp27 is over-expressed in many cancers and is associated with inhibition of chemotherapy-induced apoptosis…
Expand
2015
2015
First-line randomized phase II study of gemcitabine/cisplatin plus apatorsen or placebo in patients with advanced bladder cancer: The International Borealis-1 trial.
J. Bellmunt
,
B. Eigl
,
+11 authors
D. Petrylak
2015
Corpus ID: 78863794
4503 Background: Heat shock protein 27 (Hsp27) is over-expressed in bladder cancer (BC) and postulated to increase tumor growth…
Expand
2015
2015
Addition of apatorsen, an inhibitor of Hsp27, to first-line gemcitabine/carboplatin in advanced squamous cell lung cancer: Design of the Cedar study.
P. Schmid
,
D. Muthukumar
,
+13 authors
L. Lim
2015
Corpus ID: 78150675
TPS8111 Background: Outcomes remain poor in patients with non-small cell lung cancer (NSCLC) of squamous origin. There are few…
Expand
2015
2015
Abstract 4552: Apatorsen enhances 5-FU sensitivity in colon cancer cell SW480
Takehiro Shimada
,
M. Tsuruta
,
+4 authors
Y. Kitagawa
2015
Corpus ID: 78795722
[Background] Heat Shock Protein (HSP) 27 is a chaperone protein of small molecular weight, which protects cells in response to…
Expand
2013
2013
The Borealis-2 clinical trial: A randomized phase II study of OGX-427 plus docetaxel versus docetaxel alone in relapsed/refractory metastatic urothelial cancer.
J. Rosenberg
,
N. Hahn
,
M. Regan
,
C. Jacobs
,
P. Stewart
,
T. Choueiri
2013
Corpus ID: 220663555
TPS4577 Background: Heat shock protein 27 (Hsp27) is over-expressed in many cancers including bladder, lung, prostate, and breast…
Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our
Privacy Policy
(opens in a new tab)
,
Terms of Service
(opens in a new tab)
, and
Dataset License
(opens in a new tab)
ACCEPT & CONTINUE