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Antisickling Agents

Known as: Agents, Antisickling, antisickling agent 
Agents used to prevent or reverse the pathological events leading to sickling of erythrocytes in sickle cell conditions.
National Institutes of Health

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12 relations
Anemia, Sickle CellIn Bloodagonistsantagonists & inhibitors

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Dimethyl Adipimidatecetiedilefaproxiralhydroxyurea

Papers overview

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Review
2017
Review
2017
Different Therapeutic Interventions and Mechanisms of Action of Antisickling Agents Currently in Use in Sickle Cell Disease Management
Sickle cell disease is a genetic disorder caused by sickle haemoglobin. In many forms of the disease, the red blood cells can… 
1985
1985
Advances in the treatment of sickle cell disease in children.
Support from the national sickle cell disease program in the United States is resulting in significant advances in health care… 
1984
1984
Antisickling effect of tellurite: a potent membrane-acting agent in vitro.
Potassium tellurite (K2TeO3) was found to be a potent antisickling agent that inhibited red cell sickling at concentrations less… 
1983
1983
Interaction of phosphatidylserine-phosphatidylcholine liposomes with sickle erythrocytes. Evidence for altered membrane surface properties.
The sickle erythrocyte (RBC) is a pathologic RBC that contains multiple membrane abnormalities. Some of these abnormalities have… 
1983
1983
Reactions of spin-label cross-linking reagents with red blood cell proteins.
The reactions of two spin-label cross-linking reagents with components of red blood cells have been studied. A bifunctional bis(N… 
1982
1982
Correlation of partition coefficients with antisickling activity of simple alcohols, amides and ureas.
The resultant increase of the solubility of hemoglobin S in the presence of various alcohols, amides, and ureas has been found to… 
1982
1982
Preliminary studies of continuous extracorporeal carbamylation in the treatment of sickle cell anemia.
The lack of effective therapy of sickle cell anemia has prompted investigation of a large number of antisickling agents. The most… 
1981
1981
Use of citrate agar electrophoresis in evaluation of antisickling agents.
Hemoglobin S (Hb S), treated with antisickling agents which interfere with gel formation, has been found to migrate on citrate… 
1980
1980
Effect of cetiedil on erythrocyte sickling: new type of antisickling agent that may affect erythrocyte membranes.
The antisickling effect of cetiedil, alpha-cyclohexyl-3-thiopheneacetic acid 2-(hexahydro-1H-azepin-1-yl)-ethyl ester, has been… 
1977
1977
Ligand kinetics of hemoglobin S containing erythrocytes.
Oxygen uptake of fully deoxygenated sickle (SS) erythrocytes is slower than that of normal (AA) erythrocytes, as demonstrated by…