Antisickling Agents

Known as: Agents, Antisickling, antisickling agent 
Agents used to prevent or reverse the pathological events leading to sickling of erythrocytes in sickle cell conditions.
National Institutes of Health

Papers overview

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2003
2003
Although the molecular defect in sickle hemoglobin that produces sickle cell disease has been known for decades, there is still… (More)
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2002
2002
Among the various potential antisickling agents tested, hydroxyurea (HU) has been the most effective compound used for the… (More)
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Highly Cited
1996
Highly Cited
1996
Painful crises in patients with sickle cell anemia are caused by vaso-occlusion and infarction. Occlusion of blood vessels… (More)
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1990
1990
Amino acid analysis showed that solvent extracts of Cajanus cajan L. Millsp. (Fabaceae) seeds (white species) contain, as free… (More)
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1983
1983
Several aromatic compounds have been found to inhibit the gelling of sickle cell hemoglobin. We have tried to correlate the… (More)
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1983
1983
We have used a three-dimensional model of deoxyhemoglobin to design potential antisickling agents with an intended binding site… (More)
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Highly Cited
1978
Highly Cited
1978
From the Department of Pediatrics, University of Southern California School of Medicine, Los Angeles County-USC Medical Center… (More)
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Highly Cited
1978
Highly Cited
1978
Hypocupremia occurred in an adult with sickle cell anemia who received zinc as an antisickling agent for two years. The… (More)
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1977
1977
Acetyl-3,5-dibromosalicylic acid (dibromoaspirin) is shown to be a potent acylating agent of intracellular hemoglobin in vitro… (More)
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1975
1975
A new approach to the prevention of sickling in vitro by use of the bifunctional crosslinking reagent, dimethyl adipimidate, is… (More)
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