Antinociceptive Agents

Compounds that show activity in animal models of human PAIN such as tail flick and hot plate assays.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1970-2017
051019702017

Papers overview

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2003
2003
A number of [(3-chlorophenyl)piperazinylpropyl]pyridazinones and the corresponding isoxazolopyridazinones, showing the… (More)
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2002
2002
Objective: The interactions of α-adrenoceptors with the antinociceptive effects of non-steroidal anti-inflammatory drugs (NSAIDs… (More)
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2001
2001
Rationale: Recent studies indicate that µ opioids are generally more potent and effective as antinociceptive agents in male than… (More)
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Highly Cited
2000
Highly Cited
2000
Rationale: Recent studies indicate that morphine is more potent as an antinociceptive agent in male than female rodents and… (More)
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1998
1998
1. Debate exists as to the nature of antidepressant-induced antinociception. It is unclear whether antidepressants are inherently… (More)
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Highly Cited
1996
Highly Cited
1996
Male Sprague-Dawley rats were used to evaluate the antinociceptive properties of the selective N-type voltage-sensitive calcium… (More)
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1995
1995
Morphine-induced antinociception is antagonized by the K(+)-channel blocker glibenclamide (glyburide; Glib), implicating ATP… (More)
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Highly Cited
1995
Highly Cited
1995
Although it is well established that the analgesic effects of morphine are mediated by opioid receptors, previous studies have… (More)
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1989
1989
By employing a constant-rate (1 microliter/hr) constant-dose intrathecal infusion pump in rats, groups received a 7-day infusion… (More)
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1989
1989
By using a constant-rate, fixed concentration intrathecal infusion model, the time course of change in hot plate (HP) response… (More)
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