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Antibodies, Catalytic

Known as: Catalytic Antibody, Antibody, Catalytic, Antibodies, Catalytic [Chemical/Ingredient] 
Antibodies that can catalyze a wide variety of chemical reactions. They are characterized by high substrate specificity and share many mechanistic… 
National Institutes of Health

Related topics

Related topics

7 relations

Broader (2)

AntibodiesEnzymes
In Bloodaspects of radiation effectsphysiological aspects

Narrower (2)

abzyme 21D8m4G3 abzyme

Papers overview

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2000
2000
Reconstructing Aldolase Antibodies to Alter Their Substrate Specificity and Turnover
Fujie Tanaka, Richard A. Lerner,* and Carlos F. Barbas, III*The Skaggs Institute for Chemical Biology and theDepartment of… 
1998
1998
COFACTOR-INDUCED REFINEMENT OF CATALYTIC ANTIBODY ACTIVITY : A METAL-SPECIFIC ALLOSTERIC EFFECT
We recently described the development of the strategy of reactive immunization for the production of two catalytic antibodies for… 
1997
1997
Mechanism of inactivation of a catalytic antibody by p-nitrophenyl esters.
Antibody CNJ206 catalyses the hydrolysis of p-nitrophenyl esters with significant rate enhancement; however, after a few cycles… 
Highly Cited
1996
Highly Cited
1996
Toward antibody-directed "abzyme" prodrug therapy, ADAPT: carbamate prodrug activation by a catalytic antibody and its in vitro application to human tumor cell killing.
Antibody-directed enzyme prodrug therapy, ADEPT, is a recent approach to targeted cancer chemotherapy intended to diminish the… 
1996
1996
Targeting of Pallada- and Platinacycles to the N-((tert-Butyloxy)carbonyl)-l-methionine p-Nitrophenyl Ester for Promotion of the Ester Cleavage
Chloro-bridged cyclometalated Pd(II) or Pt(II) targeted to sulfur of N-((tert-butyloxy)carbonyl)-l-methionine p-nitrophenyl ester… 
Highly Cited
1995
Highly Cited
1995
Crystal structure of the complex of a catalytic antibody Fab fragment with a transition state analog: structural similarities in esterase-like catalytic antibodies.
The x-ray structure of the complex of a catalytic antibody Fab fragment with a phosphonate transition-state analog has been… 
1994
1994
Binding of hapten to a single-chain catalytic antibody demonstrated by electrospray mass spectrometry
Catalytic antibodies (abzymes) have been elicited for a variety of chemical reactions. Abzymes have been developed to catalyze… 
1994
1994
Un abzyme DNase polyclonal produit par la méthode de l'image interne anti-idiotypique
Le concept d'image interne de l'antigene a ete applique a la production d'anticorps catalytiques, Un anticorps anti-DNase I (Abl… 
1993
1993
Isoabzymes: structurally and mechanistically similar catalytic antibodies from the same immunization.
Mechanistic and structural comparisons of five catalytic monoclonal antibodies generated from the same hybridoma fusion indicated… 
Highly Cited
1990
Highly Cited
1990
Simple method for selecting catalytic monoclonal antibodies that exhibit turnover and specificity.
Monoclonal antibodies were raised against a mono-p-nitrophenyl phosphonate ester to elicit catalytic antibodies capable of…