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Anti-HER2 Antibody-drug Conjugate MEDI4276
Known as:
ADC MEDI4276
, MEDI-4276
, MEDI4276
An antibody-drug conjugate (ADC) composed of a bispecific antibody against the extracellular domain of human epidermal growth factor receptor 2 (HER2…
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National Institutes of Health
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Papers overview
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2016
2016
Abstract 2970: MEDI4276, a HER2-targeting antibody tubulysin conjugate, displays potent invitroandin vivoactivity in preclinical studies
John Y Li
,
D. Toader
,
+15 authors
Herren Wu
2016
Corpus ID: 78499400
Antibody drug conjugates (ADCs) combine the specificity of antibodies with the potent cytotoxicity of small molecule drugs and…
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2016
2016
A Phase 1 study to evaluate the safety, pharmacokinetics, immunogenicity, and antitumor activity of MEDI4276 in patients with select HER2-expressing advanced solid tumors.
E. Hamilton
,
M. Patel
,
+5 authors
A. Scheuber
2016
Corpus ID: 80344932
TPS632Background: Human epidermal growth factor receptor 2 (HER2) is a transmembrane tyrosine kinase receptor involved in…
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