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Anti-DLL4 Monoclonal Antibody MEDI0639
Known as:
MEDI0639
An immunoglobulin G1 lambda monoclonal antibody directed against the Notch ligand delta-like 4 (DLL4) with potential antineoplastic activity. Anti…
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National Institutes of Health
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antigen binding
Papers overview
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2016
2016
Evaluation of anti-cancer stem cell activity of the anti-DLL4 antibody MEDI0639 in a phase I clinical trial of SCLC.
H. Bao
,
Xiaoru Chen
,
+6 authors
M. Dar
2016
Corpus ID: 79426159
e20093Background: Small-cell lung cancer (SCLC) is a very aggressive lung cancer with a high metastatic potential. Many patients…
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2013
2013
Abstract 4424: Nonclinical safety evaluation of MEDI0639 (Anti-DLL4 Mab) to support first time In human: linking DLL4-notch signaling blockade to exaggerated pharmacology effects in cynomolgus…
P. Ryan
,
Jiaqi Huang
,
+8 authors
R. Dixit
2013
Corpus ID: 75992356
Delta-like ligand 4 (DLL4)-Notch signaling regulates several key stages of angiogenesis. MEDI0639 is a human IgG1 antibody that…
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