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Anti-DKK1 Monoclonal Antibody BHQ880

A humanized monoclonal antibody directed against Wnt antagonist Dickkopf-1 (DKK1) with potential anti-osteolytic activity. Anti-DKK1 monoclonal… Expand
National Institutes of Health

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BHQ880
antigen binding

Papers overview

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2019
2019
Increased anabolic bone response in Dkk1 KO mice following tibial compressive loading.
A viable Dkk1 knockout (KO) mouse strain in which embryonic lethality is rescued by developmental Wnt3 heterozygosity (Dkk1… Expand
2018
2018
MiR-613 inhibits proliferation and invasion and induces apoptosis of rheumatoid arthritis synovial fibroblasts by direct down-regulation of DKK1
BackgroundThis study aimed to investigate the effects of miR-613 on the proliferation, invasion and apoptosis of rheumatoid… Expand
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2018
2018
Dkk1 KO Mice Treated with Sclerostin Antibody Have Additional Increases in Bone Volume
Dickkopf-1 (DKK1) and sclerostin are antagonists of the Wnt/β-catenin pathway and decreased expression of either results in… Expand
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2017
2017
Homozygous Dkk1 Knockout Mice Exhibit High Bone Mass Phenotype Due to Increased Bone Formation
Wnt antagonist Dkk1 is a negative regulator of bone formation and Dkk1+/− heterozygous mice display a high bone mass phenotype… Expand
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2014
2014
Dkk1 intheperi-cloacamesenchymeregulatesformationofanorectal and genitourinarytracts
 
2010
2010
Increased Dickkopf-1 expression accelerates bone cell apoptosis in femoral head osteonecrosis.
Intensive bone cell apoptosis contributes to osteonecrosis of femoral head (ONFH). Dickkopf-1 (DKK1) reportedly mediates various… Expand
2009
2009
Identification of Achaete-scute complex-like 1 (ASCL1) target genes and evaluation of DKK1 and TPH1 expression in pancreatic endocrine tumours
BackgroundASCL1 role in pancreatic endocrine tumourigenesis has not been established. Recently it was suggested that ASCL1… Expand
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