Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Anrukinzumab

Known as: IMA-638, Immunoglobulin G1, anti-(human interleukin-13) Humanized Mouse Monoclonal Gamma 1 Heavy Chain 235L>A, 238G>A (221-218')-disulfide with Humanized Mouse Monoclonal Kappa Light Chain (227-227'':230-230'')-bisdisulfide Dimer 
A humanized monoclonal antibody directed against interleukin-13 (IL-13) with anti-asthmatic and anti-inflammatory activities. Anrukinzumab binds to… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Sufficient evidence points to interleukin 13 (IL-13) as an important pathological factor in UC and raises hopes to a promising… Expand
Is this relevant?
Review
2016
Review
2016
Asthma is a high-prevalence disease, still accounting for mortality and high direct and indirect costs. It is now recognized that… Expand
  • figure 1
  • figure 2
  • table 1
Is this relevant?
2016
2016
ABSTRACT IMA-638 and IMA-026 are humanized IgG1 monoclonal antibodies (mAbs) that target non-overlapping epitopes of IL-13… Expand
Is this relevant?
Highly Cited
2015
Highly Cited
2015
Objective Interleukin 13 (IL-13) is thought to play a key role as an effector cytokine in UC. Anrukinzumab, a humanised antibody… Expand
Is this relevant?
2015
2015
AIMS Anrukinzumab is an anti-IL13 monoclonal antibody. The goals of this study are to characterize the pharmacokinetics of… Expand
Is this relevant?
2012
2012
  • Dave Holmes
  • Nature Reviews Drug Discovery
  • 2012
  • Corpus ID: 21331984
After decades of stubbornly slow progress in asthma drug development, recent results from a trial of GlaxoSmithKline's… Expand
Is this relevant?
Highly Cited
2011
Highly Cited
2011
RATIONALE Extensive evidence in animal models supports a role for IL-13 in the pathobiology of asthma. IMA-638 and IMA-026 are… Expand
Is this relevant?
2011
2011
Human studies using Abs to two different, nonoverlapping epitopes of IL-13 suggested that epitope specificity can have a… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2007
Highly Cited
2007
BACKGROUND Airway inflammation is a hallmark feature of asthma and a driver of airway hyperresponsiveness. IL-13 is a key inducer… Expand
Is this relevant?
Highly Cited
2007
Highly Cited
2007
IL-13 contributes to airway hyperresponsiveness, mucus secretion, inflammation, and fibrosis, suggesting that it plays a central… Expand
  • table 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?