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Interleukin (IL)-13 is a cytokine playing a pivotal role in T helper (Th)2 immune response supposed to be implicated in some… Expand Asthma is a high-prevalence disease, still accounting for mortality and high direct and indirect costs. It is now recognized that… Expand ABSTRACT IMA-638 and IMA-026 are humanized IgG1 monoclonal antibodies (mAbs) that target non-overlapping epitopes of IL-13… Expand Objective Interleukin 13 (IL-13) is thought to play a key role as an effector cytokine in UC. Anrukinzumab, a humanised antibody… Expand AIMS
Anrukinzumab is an anti-IL13 monoclonal antibody. The goals of this study are to characterize the pharmacokinetics of… Expand After decades of stubbornly slow progress in asthma drug development, recent results from a trial of GlaxoSmithKline's… Expand RATIONALE
Extensive evidence in animal models supports a role for IL-13 in the pathobiology of asthma. IMA-638 and IMA-026 are… Expand Human studies using Abs to two different, nonoverlapping epitopes of IL-13 suggested that epitope specificity can have a… Expand BACKGROUND
Airway inflammation is a hallmark feature of asthma and a driver of airway hyperresponsiveness. IL-13 is a key inducer… Expand IL-13 contributes to airway hyperresponsiveness, mucus secretion, inflammation, and fibrosis, suggesting that it plays a central… Expand