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Anrukinzumab

Known as: IMA-638, Immunoglobulin G1, anti-(human interleukin-13) Humanized Mouse Monoclonal Gamma 1 Heavy Chain 235L>A, 238G>A (221-218')-disulfide with Humanized Mouse Monoclonal Kappa Light Chain (227-227'':230-230'')-bisdisulfide Dimer 
A humanized monoclonal antibody directed against interleukin-13 (IL-13) with anti-asthmatic and anti-inflammatory activities. Anrukinzumab binds to… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Interleukin (IL)-13 is a cytokine playing a pivotal role in T helper (Th)2 immune response supposed to be implicated in some… Expand
Review
2016
Review
2016
Asthma is a high-prevalence disease, still accounting for mortality and high direct and indirect costs. It is now recognized that… Expand
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2016
2016
ABSTRACT IMA-638 and IMA-026 are humanized IgG1 monoclonal antibodies (mAbs) that target non-overlapping epitopes of IL-13… Expand
Highly Cited
2015
Highly Cited
2015
Objective Interleukin 13 (IL-13) is thought to play a key role as an effector cytokine in UC. Anrukinzumab, a humanised antibody… Expand
2015
2015
AIMS Anrukinzumab is an anti-IL13 monoclonal antibody. The goals of this study are to characterize the pharmacokinetics of… Expand
2012
2012
  • D. Holmes
  • Nature Reviews Drug Discovery
  • 2012
  • Corpus ID: 21331984
After decades of stubbornly slow progress in asthma drug development, recent results from a trial of GlaxoSmithKline's… Expand
Highly Cited
2011
Highly Cited
2011
RATIONALE Extensive evidence in animal models supports a role for IL-13 in the pathobiology of asthma. IMA-638 and IMA-026 are… Expand
Highly Cited
2011
Highly Cited
2011
Human studies using Abs to two different, nonoverlapping epitopes of IL-13 suggested that epitope specificity can have a… Expand
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Airway inflammation is a hallmark feature of asthma and a driver of airway hyperresponsiveness. IL-13 is a key inducer… Expand
Highly Cited
2007
Highly Cited
2007
IL-13 contributes to airway hyperresponsiveness, mucus secretion, inflammation, and fibrosis, suggesting that it plays a central… Expand
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