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Anchorage-Independent Growth

An assay to determine the ability of cells to grow unattached to a substrate. It is an indication that the cells have been transformed.
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
Overcoming metabolic stress is a critical step for solid tumour growth. However, the underlying mechanisms of cell death and… Expand
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Highly Cited
2010
Highly Cited
2010
Otto Warburg's theory on the origins of cancer postulates that tumor cells have defects in mitochondrial oxidative… Expand
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Highly Cited
2008
Highly Cited
2008
The family of 14-3-3 proteins has emerged as critical regulators of diverse cellular responses under both physiological and… Expand
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Highly Cited
2008
Highly Cited
2008
The phosphatase of regenerating liver (PRL) family, a unique class of oncogenic phosphatases, consists of three members: PRL-1… Expand
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Highly Cited
2006
Highly Cited
2006
The high rate of glycolysis despite the presence of oxygen in tumor cells (Warburg effect) suggests an important role for this… Expand
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Highly Cited
2006
Highly Cited
2006
ABSTRACT Current understanding of the activation of STATs is through binding between the SH2 domain of STATs and phosphotyrosine… Expand
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Highly Cited
2005
Highly Cited
2005
Saturated and monounsaturated fatty acids are the most abundant fatty acid species in mammalian organisms, and their distribution… Expand
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Highly Cited
2002
Highly Cited
2002
p21-activated protein kinase (PAK) serine/threonine kinases are important effectors of Rho family GTPases and have been… Expand
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Highly Cited
2002
Highly Cited
2002
Caveolin-1 is an essential structural constituent of caveolae that has been implicated in mitogenic signaling and oncogenesis… Expand
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Highly Cited
2000
Highly Cited
2000
The position of the point mutation in the c-K-ras gene appears associated with different degrees of aggressiveness in human… Expand
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