Amino Acid Metabolism, Inborn Errors
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As next-generation sequencing projects generate massive genome-wide sequence variation data, bioinformatics tools are being… Expand Metabolomic profiling of obese versus lean humans reveals a branched-chain amino acid (BCAA)-related metabolite signature that is… Expand Tumor cell proliferation requires rapid synthesis of macromolecules including lipids, proteins, and nucleotides. Many tumor cells… Expand Familial parkinsonism and dementia with cortical and subcortical Lewy bodies is uncommon, and no genetic defect has been reported… Expand The cycloaddition of azides to alkynes is one of the most important synthetic routes to 1H-[1,2,3]-triazoles. Here a novel… Expand In many neurologic disorders, injury to neurons may be caused at least in part by overstimulation of receptors for excitatory… Expand AS methods for determining protein three-dimensional (3D) structure develop, a continuing problem is how to verify that the final… Expand A LOCUS segregating with familial Alzheimer's disease (AD) has been mapped to chromosome 21 (ref. 1), close to the amyloid… Expand PROTEINS often differ in amino-acid sequence across species. This difference has evolved by the accumulation of neutral mutations… Expand A computer adaptable method for finding similarities in the amino acid sequences of two proteins has been developed. From these… Expand