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Alpha-Amanitin

Known as: Alpha Amanitine, Alpha Amanitin, Alpha-Amanitine 
A cyclic octapeptide with a thioether bridge between the cystine and tryptophan. It inhibits RNA POLYMERASE II. Poisoning may require LIVER… Expand
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Structural, biochemical, and genetic studies have led to proposals that a mobile element of multisubunit RNA polymerases, the… Expand
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Highly Cited
2006
Highly Cited
2006
Amatoxins are the main poison of the green death cap (Amanita phalloides) and among the most dangerous natural toxins causing… Expand
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Highly Cited
2004
Highly Cited
2004
MicroRNAs (miRNAs) constitute a large family of noncoding RNAs that function as guide molecules in diverse gene silencing… Expand
Highly Cited
2004
Highly Cited
2004
To investigate the role of stored and neosynthesized mRNAs in seed germination, we examined the effect of α-amanitin, a… Expand
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Highly Cited
2003
Highly Cited
2003
Objective—Peroxisome proliferator-activated receptor &ggr; (PPAR&ggr;) ligands reduce lesion formation in animal models of… Expand
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Highly Cited
1999
Highly Cited
1999
Analysis of the relationship between transcriptional activators and chromatin organization has focused largely on lower levels of… Expand
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Highly Cited
1996
Highly Cited
1996
Alpha-Amanitin is a well-known specific inhibitor of RNA polymerase II (RNAPII) in vitro and in vivo. It is a cyclic octapeptide… Expand
Highly Cited
1994
Highly Cited
1994
Freshly isolated mouse hepatocytes were essentially insensitive to TNF-alpha cytotoxicity. However, TNF-alpha induced a… Expand
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Highly Cited
1993
Highly Cited
1993
HeLa cells were encapsulated in agarose microbeads, permeabilized and incubated with Br‐UTP in a ‘physiological’ buffer; then… Expand
Highly Cited
1982
Highly Cited
1982
The development of the early 2‐cell mouse embryo to the late 2‐cell stage is marked by the appearance between 23 and 26 h post… Expand