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Alpha-Amanitin

Known as: Alpha Amanitine, Alpha Amanitin, Alpha-Amanitine 
A cyclic octapeptide with a thioether bridge between the cystine and tryptophan. It inhibits RNA POLYMERASE II. Poisoning may require LIVER… Expand
National Institutes of Health

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Highly Cited
2009
Highly Cited
2009
ABSTRACT The positive regulatory machinery in the microRNA (miRNA) processing pathway is relatively well characterized, but… Expand
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Highly Cited
2008
Highly Cited
2008
Structural, biochemical, and genetic studies have led to proposals that a mobile element of multisubunit RNA polymerases, the… Expand
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Highly Cited
2007
Highly Cited
2007
Brain-derived neurotrophic factor (BDNF) plays an important role in synaptic plasticity in the hippocampus, but the mechanisms… Expand
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Highly Cited
2006
Highly Cited
2006
Amatoxins are the main poison of the green death cap (Amanita phalloides) and among the most dangerous natural toxins causing… Expand
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Highly Cited
2004
Highly Cited
2004
MicroRNAs (miRNAs) constitute a large family of noncoding RNAs that function as guide molecules in diverse gene silencing… Expand
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Highly Cited
2004
Highly Cited
2004
To investigate the role of stored and neosynthesized mRNAs in seed germination, we examined the effect of α-amanitin, a… Expand
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Highly Cited
2003
Highly Cited
2003
Objective—Peroxisome proliferator-activated receptor &ggr; (PPAR&ggr;) ligands reduce lesion formation in animal models of… Expand
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Highly Cited
2002
Highly Cited
2002
Information storage in the brain is a temporally graded process involving different memory types or phases. It has been assumed… Expand
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Highly Cited
1999
Highly Cited
1999
Analysis of the relationship between transcriptional activators and chromatin organization has focused largely on lower levels of… Expand
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Highly Cited
1996
Highly Cited
1996
Alpha-Amanitin is a well-known specific inhibitor of RNA polymerase II (RNAPII) in vitro and in vivo. It is a cyclic octapeptide… Expand
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