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Allylisopropylacetamide

Known as: 2-(1-Methylethyl)-4-pentenamide, Allylisopropylacetamide [Chemical/Ingredient], 4-Pentenamide, 2-(1-methylethyl)- 
An allylic compound that acts as a suicide inactivator of CYTOCHROME P450 by covalently binding to its heme moiety or surrounding protein.
National Institutes of Health

Papers overview

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Highly Cited
1998
Highly Cited
1998
This study examined the ability of several inhibitors of mammalian cytochrome P450s to affect hepatic P450-mediated monooxygenase… Expand
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1987
1987
In vivo administration of the porphyrogenic agent allylisopropylacetamide (AIA) to phenobarbital-pretreated rats results in… Expand
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1984
1984
Administration of 2-isopropyl-4-pentenamide (AIA) and 2,2-diethyl-4-pentenamide (novonal) to phenobarbital-pretreated rats gives… Expand
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Highly Cited
1983
Highly Cited
1983
Succinylacetone (4,6-dioxoheptanoic acid) is an abnormal metabolite produced in patients with hereditary tyrosinemia as a… Expand
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1982
1982
The "major" phenobarbital (PB)-induced cytochrome P-450 species present in livers of male Sprague-Dawley rats was resolved into… Expand
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1981
1981
Abstract The autocatalytic destruction of cytochrome P-450 by the following six substrates has been investigated in vivo and in… Expand
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1981
1981
The hepatic pigment accumulated in 3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated rats, which has been reported to inhibit… Expand
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Highly Cited
1977
Highly Cited
1977
Abstract In order to define the site of bioactivation of CCl 4 , CHCl 3 and CBrCl 3 in the NADPH cytochrome c reductase… Expand
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Highly Cited
1975
Highly Cited
1975
The administration of cobalt to rats caused a marked increase in the oxidative degradation of heme (hematin, iron protoporphyrin… Expand
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Highly Cited
1970
Highly Cited
1970
The quantitative relationship between the catabolism of heme and the formation of bilirubin and carbon monoxide (CO) was studied… Expand
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