Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Allylisopropylacetamide

Known as: 2-(1-Methylethyl)-4-pentenamide, Allylisopropylacetamide [Chemical/Ingredient], 4-Pentenamide, 2-(1-methylethyl)- 
An allylic compound that acts as a suicide inactivator of CYTOCHROME P450 by covalently binding to its heme moiety or surrounding protein.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1982
Highly Cited
1982
The "major" phenobarbital (PB)-induced cytochrome P-450 species present in livers of male Sprague-Dawley rats was resolved into… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Highly Cited
1981
Highly Cited
1981
Abstract The autocatalytic destruction of cytochrome P-450 by the following six substrates has been investigated in vivo and in… Expand
Highly Cited
1981
Highly Cited
1981
The hepatic pigment accumulated in 3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated rats, which has been reported to inhibit… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Highly Cited
1977
Highly Cited
1977
Abstract In order to define the site of bioactivation of CCl4, CHCl3 and CBrCl3 in the NADPH cytochrome c reductase-cytochrome P… Expand
Highly Cited
1975
Highly Cited
1975
The administration of cobalt to rats caused a marked increase in the oxidative degradation of heme (hematin, iron protoporphyrin… Expand
  • figure 1
  • table I
  • table II
  • figure 3
  • figure 4
Highly Cited
1972
Highly Cited
1972
Abstract Administration of allylisopropylacetamide (AIA) or CCl 4 to rats previously treated with phenobarbital leads to a rapid… Expand
Highly Cited
1971
Highly Cited
1971
Excessive induction of δ-aminolevulinic acid synthetase in rats after treatment with porphyria-inducing chemicals, such as… Expand
Highly Cited
1971
Highly Cited
1971
The process by which various anions, including bilirubin and several dyes, drugs, hormones and their metabolites, are transferred… Expand
  • table I
  • table I
  • figure 1
  • figure 2
  • figure 3
Highly Cited
1969
Highly Cited
1969
Abstract When the synthesis of hepatic ALA synthetase was induced in rats by the administration of allylisopropylacetamide, high… Expand
Highly Cited
1965
Highly Cited
1965
Acute intermittent porphyria is an inborn error of metabolism characterized chemically by the excretion in the urine of excessive… Expand