Allylisopropylacetamide

Known as: 2-(1-Methylethyl)-4-pentenamide, Allylisopropylacetamide [Chemical/Ingredient], 4-Pentenamide, 2-(1-methylethyl)- 
An allylic compound that acts as a suicide inactivator of CYTOCHROME P450 by covalently binding to its heme moiety or surrounding protein.
National Institutes of Health

Papers overview

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Review
1988
Review
1988
Heme biosynthesis in hepatocytes is controlled by a free heme pool, which regulates delta-aminolevulinic acid synthase… (More)
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1987
1987
In vivo administration of the porphyrogenic agent allylisopropylacetamide (AIA) to phenobarbital-pretreated rats results in… (More)
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1987
1987
In rat liver, allylisopropylacetamide (AIA) treatment strongly induced (25-fold) the activity of rat hepatic ornithine… (More)
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1984
1984
Administration of 2-isopropyl-4-pentenamide (AIA) and 2,2-diethyl-4-pentenamide (novonal) to phenobarbital-pretreated rats gives… (More)
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1983
1983
The influence of pretreatment with allylisopropylacetamide (AIA) and phenobarbital (PB) on the pharmacokinetics and metabolite… (More)
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1982
1982
Changes in hepatic mixed function oxidase kinetics after administration of allylisopropylacetamide (AIA) to chick embryos… (More)
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1978
1978
Two structural genes, β major and β minor, are present at the β-globin locus (Hbb) of a variety of mice phenotypically… (More)
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1971
1971
Excessive induction of delta-aminolevulinic acid synthetase in rats after treatment with porphyria-inducing chemicals, such as… (More)
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1971
1971
Treatment of rats with allylisopropylacetamide results in two related effects that occur sequentially. After one injection, serum… (More)
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1969
1969
VITAMIN E deficiency in experimental animals is characterized by species specific manifestations affecting a variety of tissues… (More)
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