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Allogeneic T-Lymphocytes BPX-501

Known as: BPX-501 
Allogeneic, T-lymphocytes with potential immune reconstitution activity. Donor T-lymphocytes are transduced with a retroviral vector (BPZ-1001… 
National Institutes of Health

Papers overview

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2018
2018
Administration of BPX-501 Following α-T and B-Cell Depleted Haplo-HSCT in Children with Transfusion-Dependent Thalassemia
Background Allogeneic hematopoietic stem cell transplantation (HSCT) from an HLA-identical sibling has been shown to cure… 
2018
2018
T- and B-Cell Neogenesis Recovers Efficiently in Children with Acute Leukemia Given an Alpha-Beta T-Cell Depleted Haplo-HSCT Followed By Infusion of Donor T-Cells Genetically Modified with Inducible…
Background αβ T- and B-cell depleted HLA-haploidentical HSCT (αβ haplo-HSCT) is an alternative promptly available and… 
2018
2018
Administration of BPX-501 Cells Following Αβ- T and B-Cell-Depleted HLA-Haploidentical HSCT in Children with Fanconi Anemia
Background Allogeneic hematopoietic stem cell transplantation (HSCT) has been shown to rescue trilineage cytopenias and to… 
2016
2016
Clinical Outcome and Immune Recovery after Adoptive Infusion of BPX-501 Cells (donor T cells transduced with iC9 suicide gene) in Children with Hemoglobinopathies and Diamond-Blackfan Anemia Given…
Background: Allogeneic HSCT from either an HLA-identical sibling or an unrelated donor is a potentially curative treatment for… 
2015
2015
Clinical Outcome after Adoptive Infusion of BPX-501 Cells (donor T cells transduced with iC9 suicide gene) in Children Given Alpha/Beta T-Cell Depleted HLA-Haploidentical Hematopoietic Stem Cell…
Background: We recently completed a prospective study (ClinicalTrial.gov identifier: [NCT01810120][1]) which showed that haplo… 
2015
2015
BPX-501 Cells (donor T cells transduced with iC9 suicide gene) Are Able to Clear Life-Threatening Viral Infections in Children with Primary Immune Deficiencies Given Alpha/Beta T-Cell Depleted HLA…
Background: T-cell depleted haplo-HSCT is an established treatment for children with primary immune deficiencies (PID). However… 
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