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Allele-Specific Oligonucleotide

Known as: ASO 
An oligonucleotide designed to be specific for only one allele of a gene.
National Institutes of Health

Papers overview

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2000
2000
The allele frequency of mutations in four genes that confer enhanced susceptibility to venous thromboembolism in an unselected group of New York State newborns.
The frequencies of Factor V G1691A (FVL), prothrombin (PT) G20210A, 5'10'methylenetetrahydrofolate reductase (MTHFR) C677T, and… Expand
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Highly Cited
2000
Highly Cited
2000
Rapid and reliable quantification of minimal residual disease in acute lymphoblastic leukemia using rearranged immunoglobulin and T-cell receptor loci by LightCycler technology.
The detection of minimal residual disease (MRD) using immunoglobulin and T-cell receptor (TCR) rearrangements as PCR targets… Expand
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Review
2000
Review
2000
High-throughput genotyping assay approaches.
  • P. Kwok
  • Pharmacogenomics
  • 2000
    • Corpus ID: 7012247
High-throughput genotyping approaches are being developed to meet the demands of pharmacogenomnics, where numerous individuals… Expand
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Highly Cited
1999
Highly Cited
1999
Rapid detection of CYP1A1, CYP2D6, and NAT variants by multiplex polymerase chain reaction and allele-specific oligonucleotide assay.
Drugs and carcinogens are excreted from the body after metabolic conversion involving enzymes mediating oxidative metabolism and… Expand
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Highly Cited
1999
Highly Cited
1999
The histopathology of fibrous dysplasia of bone in patients with activating mutations of the Gs alpha gene: site-specific patterns and recurrent histological hallmarks.
Gs alpha mutations and histopathology have been analysed in a series of 13 patients with fibrous dysplasia (FD) of bone… Expand
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Highly Cited
1999
Highly Cited
1999
Proportion of cystic fibrosis gene mutations not detected by routine testing in men with obstructive azoospermia.
CONTEXT Infertile men with obstructive azoospermia may have mutations in the cystic fibrosis transmembrane conductance regulator… Expand
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1995
1995
Fluorescence‐based oligonucleotide ligation assay for analysis of cystic fibrosis transmembrane conductance regulator gene mutations
Isolation of the gene for cystic fibrosis (CF), the cystic fibrosis transmembrane conductance regulator (CFTR), provided a basis… Expand
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Highly Cited
1994
Highly Cited
1994
Rapid determination of platelet alloantigen genotypes by polymerase chain reaction using allele-specific primers.
BACKGROUND The technique of allele-specific polymerase chain reaction (PCR) amplification has been adapted for DNA-based human… Expand
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Highly Cited
1991
Highly Cited
1991
Prenatal diagnosis of neonatal alloimmune thrombocytopenia using allele-specific oligonucleotide probes.
The prediction of neonatal alloimmune thrombocytopenia (NATP) in affected families has, in the past, been based on information… Expand
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Highly Cited
1989
Highly Cited
1989
A missense mutation in the neutrophil cytochrome b heavy chain in cytochrome-positive X-linked chronic granulomatous disease.
A membrane-bound cytochrome b, a heterodimer formed by a 91-kD glycoprotein and a 22-kD polypeptide, is a critical component of… Expand
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