Alkyltransferases

Known as: alkyltransferase 
 
National Institutes of Health

Papers overview

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Review
2004
Review
2004
The DNA-repair protein O6-alkylguanine DNA alkyltransferase (AGT) has a wide range of activity in normal tissues and its… (More)
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Review
2004
Review
2004
Alkylation lesions in DNA and RNA result from endogenous compounds, environmental agents and alkylating drugs. Simple methylating… (More)
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Highly Cited
2003
Highly Cited
2003
Temozolomide, an oral DNA methylator that inactivates the DNA repair enzyme O6-alkylguanine-DNA alkyltransferase (AGAT), has… (More)
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Review
2003
Review
2003
O(6)-Alkylguanine-DNA alkyltransferase (ATase) confers resistance to many of the biological effects of certain classes of… (More)
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Highly Cited
2003
Highly Cited
2003
We report here the generation of mutants of the human O(6)-alkylguanine-DNA alkyltransferase (hAGT) for the efficient in vivo… (More)
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Highly Cited
1998
Highly Cited
1998
PURPOSE We evaluated the response to Temodal (Schering-Plough Research Institute, Kenilworth, NJ) of patients with newly… (More)
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Highly Cited
1996
Highly Cited
1996
We tested the hypothesis that the level of the DNA repair protein O6-alkylguanine-DNA alkyltransferase in brain tumors was… (More)
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Highly Cited
1996
Highly Cited
1996
Cells with the mutator phenotype are tolerant to methylating damage from N-methylnitrosourea and N-methyl-N'-nitro-N… (More)
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Review
1990
Review
1990
Alkylating agents and compounds converted metabolically to alkylating agents form an important class of carcinogens and mutagens… (More)
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Highly Cited
1990
Highly Cited
1990
O6-Alkylguanine-DNA alkyltransferase was rapidly and irreversibly inactivated by exposure to O6-benzylguanine or the p… (More)
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