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Alkaline phosphatase isoenzyme, bone fraction

Known as: BSAP, bALP, alkaline phosphatase bone 
An isoform of alkaline phosphatase found on the surface of osteoblasts. The level of this enzyme in a patient's serum is proportional to the amount… 
National Institutes of Health

Related topics

Related topics

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Bone Specific Alkaline Phosphatase Measurement

Papers overview

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Highly Cited
2011
Highly Cited
2011
Single‐dose, placebo‐controlled, randomized study of AMG 785, a sclerostin monoclonal antibody
Sclerostin, an osteocyte‐secreted protein, negatively regulates osteoblasts and inhibits bone formation. In this first‐in‐human… 
Highly Cited
2006
Highly Cited
2006
Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial.
CONTEXT The optimal duration of treatment of women with postmenopausal osteoporosis is uncertain. OBJECTIVE To compare the… 
Highly Cited
2004
Highly Cited
2004
A Single‐Dose Placebo‐Controlled Study of AMG 162, a Fully Human Monoclonal Antibody to RANKL, in Postmenopausal Women
The safety and bone antiresorptive effect of a single subcutaneous dose of AMG 162, a human monoclonal antibody to RANKL, was… 
Highly Cited
2003
Highly Cited
2003
Role of RANK ligand in mediating increased bone resorption in early postmenopausal women.
Studies in rodents have implicated various cytokines as paracrine mediators of increased osteoclastogenesis during estrogen… 
Highly Cited
2001
Highly Cited
2001
Bap, a Staphylococcus aureus Surface Protein Involved in Biofilm Formation
ABSTRACT Identification of new genes involved in biofilm formation is needed to understand the molecular basis of strain… 
Highly Cited
2000
Highly Cited
2000
Biochemical Markers of Bone Turnover, Endogenous Hormones and the Risk of Fractures in Postmenopausal Women: The OFELY Study
The mechanisms leading to increased bone loss and skeletal fragility in women with postmenopausal osteoporosis are still poorly… 
Highly Cited
2000
Highly Cited
2000
Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women.
BACKGROUND No published studies have directly examined the effect of soy protein with isoflavones on bone or bone turnover in… 
Highly Cited
1996
Highly Cited
1996
Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis
Changes of bone turnover with aging are responsible for bone loss and play a major role in osteoporosis. Although an increase of… 
Highly Cited
1996
Highly Cited
1996
Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism.
Acquired hypogonadism is being increasingly recognized in adult men. However, the effects of long term testosterone replacement… 
Highly Cited
1994
Highly Cited
1994
Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment.
To evaluate the clinical utility of recently developed biochemical markers of bone turnover to monitor the response of… 
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