Alfentanil

Known as: Alfentanil [Chemical/Ingredient], Alfentanilum, N-(1-(2-(4-Ethyl-5-oxo-2-tetrazolin-1-yl)ethyl)-4-(methoxymethyl)-4-piperidyl)propionanilide 
A synthetic short-acting opioid with analgesic and local anesthesia enhancing activity. Alfentanil primarily binds to mu-opioid receptor, a G-protein… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1979-2017
05010019792017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
BACKGROUND The efflux transporter P-glycoprotein, a member of the adenosine triphosphate-binding cassette superfamily, is a major… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2001
Highly Cited
2001
BACKGROUND The authors used the analgesics alfentanil, S(+)-ketamine, and systemic lidocaine to examine a new human model of… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
BACKGROUND Despite widespread use, little is known about the comparative pharmacokinetics of intrathecally administered opioids… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1997
Highly Cited
1997
BACKGROUND The bispectral index (BIS), a value derived from the electroencephalograph (EEG), has been proposed as a measure of… (More)
Is this relevant?
Highly Cited
1997
Highly Cited
1997
BACKGROUND The bispectral index (BIS), a parameter derived from the electroencephalograph (EEG), has been shown to correlate with… (More)
Is this relevant?
Highly Cited
1997
Highly Cited
1997
BACKGROUND Previous studies have reported conflicting results concerning the influence of age and gender on the pharmacokinetics… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
BACKGROUND Remifentanil is an esterase-metabolized opioid with a rapid clearance. The aim of this study was to contrast the… (More)
Is this relevant?
Highly Cited
1995
Highly Cited
1995
BACKGROUND The context-sensitive half-time, rather than the terminal elimination half-life, has been proposed as a more… (More)
Is this relevant?
Highly Cited
1987
Highly Cited
1987
The effect of increasing age on the dose of fentanyl or alfentanil required to produce the same electroencephalographic (EEG… (More)
Is this relevant?
Highly Cited
1985
Highly Cited
1985
Fentanyl and alfentanil produce very similar electroencephalographic (EEG) changes in humans. With increasing serum… (More)
Is this relevant?