Aldose Reductase Inhibitor

Known as: Aldehyde Reductase 1 Inhibitor 
Any substance that inhibits aldehyde reductase (aldose reductase), an enzyme that participates in glucose metabolism and osmoregulation. Aldehyde… (More)
National Institutes of Health

Papers overview

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Review
2008
Review
2008
Diabetic neuropathy is one of the most common long-term complications in patients with diabetes mellitus, with a prevalence of 60… (More)
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Highly Cited
2006
Highly Cited
2006
OBJECTIVE We sought to evaluate the long-term efficacy and safety of epalrestat, an aldose reductase inhibitor, on diabetic… (More)
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Highly Cited
2002
Highly Cited
2002
Aldose reductase inhibitors (ARIs) prevent peripheral nerve dysfunction and morphological abnormalities in diabetic animal models… (More)
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Highly Cited
2001
Highly Cited
2001
The present study was designed to examine the effect of aldose reductase (AR) overexpression on the development of diabetic… (More)
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Highly Cited
1996
Highly Cited
1996
Rats developed tactile allodynia within days of the onset of diabetes and which persisted for up to 8 weeks. Allodynia was… (More)
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Highly Cited
1994
Highly Cited
1994
Metabolic and vascular factors have been invoked in the pathogenesis of diabetic neuropathy but their interrelationships are… (More)
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1992
1992
The mechanism was studied by which isoliquiritigenin, a new aldose reductase inhibitor purified from licorice (Glycyrrhizae radix… (More)
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1989
1989
The earliest histopathologic signs of diabetic retinopathy include selective loss of intramural pericytes and thickening of… (More)
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Highly Cited
1983
Highly Cited
1983
A twofold thickening of capillary basement membranes of rat retinas resulting from dietary galactose was prevented by sorbinil… (More)
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1973
1973
An orally active inhibitor of aldose reductase, 1,3-dioxo-1H-benz[de]-isoquinoline-2(3H)acetic acid (AY-22,284), prevented… (More)
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