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Adeno-Associated Virus Type 2
Known as:
AAV2
, Adeno-Associated Virus-2
This strain of viridae is a non-pathogenic human parvovirus that is icosahedral, 20-25 nm in diameter, minus sense, and comprised of a 5 kb. single…
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National Institutes of Health
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Highly Cited
2015
Highly Cited
2015
An essential receptor for adeno-associated virus infection
Sirika Pillay
,
N. Meyer
,
+9 authors
J. Carette
Nature
2015
Corpus ID: 4402297
Adeno-associated virus (AAV) vectors are currently the leading candidates for virus-based gene therapies because of their broad…
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Highly Cited
2010
Highly Cited
2010
Prevalence of serum IgG and neutralizing factors against adeno-associated virus (AAV) types 1, 2, 5, 6, 8, and 9 in the healthy population: implications for gene therapy using AAV vectors.
S. Boutin
,
Virginie Monteilhet
,
+4 authors
C. Masurier
Human Gene Therapy
2010
Corpus ID: 5477749
Adeno-associated viruses (AAVs) are small, nonenveloped single-stranded DNA viruses that require helper viruses to facilitate…
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Highly Cited
2008
Highly Cited
2008
Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injection.
C. Zincarelli
,
S. Soltys
,
G. Rengo
,
J. Rabinowitz
Molecular Therapy
2008
Corpus ID: 12511907
This study examines transgene expression and biodistribution of adeno-associated virus (AAV) pseudotyped 1-9 after tail vein (TV…
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Highly Cited
2002
Highly Cited
2002
Cross-Packaging of a Single Adeno-Associated Virus (AAV) Type 2 Vector Genome into Multiple AAV Serotypes Enables Transduction with Broad Specificity
J. Rabinowitz
,
F. Rolling
,
+4 authors
R. Samulski
Journal of Virology
2002
Corpus ID: 10791690
ABSTRACT The serotypes of adeno-associated virus (AAV) have the potential to become important resources for clinical gene therapy…
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Highly Cited
2002
Highly Cited
2002
Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy
G. Gao
,
Mauricio Alvira
,
Lili Wang
,
R. Calcedo
,
J. Johnston
,
James M. Wilson
Proceedings of the National Academy of Sciences…
2002
Corpus ID: 6873086
Tissues from rhesus monkeys were screened by PCR for the presence of sequences homologous to known adeno-associated virus (AAV…
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Highly Cited
2002
Highly Cited
2002
The VP1 capsid protein of adeno-associated virus type 2 is carrying a phospholipase A2 domain required for virus infectivity.
A. Girod
,
C. Wobus
,
+5 authors
M. Hallek
Journal of General Virology
2002
Corpus ID: 45243505
The unique region of the VP1 protein of parvoviruses was proposed to contain a parvoviral phospholipase A2 (pvPLA2) motif. Here…
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Highly Cited
2001
Highly Cited
2001
DNA helicase‐mediated packaging of adeno‐associated virus type 2 genomes into preformed capsids
J. King
,
R. Dubielzig
,
D. Grimm
,
J. Kleinschmidt
EMBO Journal
2001
Corpus ID: 43474470
Helicases not only catalyse the disruption of hydrogen bonding between complementary regions of nucleic acids, but also move…
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Highly Cited
2000
Highly Cited
2000
Epitope Mapping of Human Anti-Adeno-Associated Virus Type 2 Neutralizing Antibodies: Implications for Gene Therapy and Virus Structure
M. Moskalenko
,
Lili Chen
,
+4 authors
Salil D. Patel
Journal of Virology
2000
Corpus ID: 20155599
ABSTRACT Recombinant adeno-associated virus type 2 (AAV) is a common vector used in human gene therapy protocols. We…
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Highly Cited
1999
Highly Cited
1999
Genetic capsid modifications allow efficient re-targeting of adeno-associated virus type 2
A. Girod
,
M. Ried
,
+5 authors
M. Hallek
Nature Network Boston
1999
Corpus ID: 35025783
The human parvovirus adeno-associated virus type 2 (AAV2) has many features that make it attractive as a vector for gene therapy…
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Highly Cited
1998
Highly Cited
1998
Infectious Clones and Vectors Derived from Adeno-Associated Virus (AAV) Serotypes Other Than AAV Type 2
E. Rutledge
,
C. Halbert
,
D. Russell
Journal of Virology
1998
Corpus ID: 6647704
ABSTRACT Adeno-associated viruses (AAVs) are single-stranded dependent parvoviruses being developed as transducing vectors…
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