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Adecatumumab

A recombinant human IgG1 monoclonal antibody (MoAb) directed against the tumor associated antigen (TAA) epithelial cell adhesion molecule (EpCAM… Expand
National Institutes of Health

Papers overview

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2012
2012
BACKGROUND Targeted therapy options in HER2-negative breast cancer are limited. This open-label, multicenter phase IB dose… Expand
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Highly Cited
2010
Highly Cited
2010
BACKGROUND High-level expression of epithelial cell adhesion molecule (EpCAM) is associated with unfavorable prognosis in breast… Expand
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2010
2010
We evaluated the expression of epithelial cell adhesion molecule (EpCAM) and the potential of MT201 (adecatumumab), a human… Expand
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2010
2010
Background: Rising serum levels of prostate-specific antigen (PSA) after radical prostatectomy are indicative of recurrent… Expand
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Highly Cited
2010
Highly Cited
2010
BackgroundEpithelial cell adhesion molecule (EpCAM) is frequently and highly expressed on human carcinomas. The emerging role of… Expand
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2010
2010
TOTHEEDITOR: In their editorial, Schmoll and Arnold 1 discussed possible reasons for the ultimate failure of anti– epithelial… Expand
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2007
2007
An important mode of action shared by human IgG1 antibody therapies is antibody-dependent cellular cytotoxicity (ADCC). ADCC… Expand
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2007
2007
Micromet Inc, in collaboration with Merck Serono SA, is developing adecatumumab for the potential treatment of adenocarcinomas… Expand
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2006
2006
AIM OF THE STUDY Adecatumumab (also known as MT201) is a human recombinant IgG1 monoclonal antibody binding with low affinity to… Expand
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Highly Cited
2006
Highly Cited
2006
A common feature of human IgG1 antibodies used for cancer treatment is that their anti-tumour efficacy requires high serum trough… Expand
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