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Ad5CMV-p53 gene

Known as: Adeno-p53, Adenovirus p53, Ad5CMV-p53 
A replication-defective adenoviral-CMV vector that encodes a wild-type p53 gene. Ad5CMV-p53 induces tumor cells that have been transfected with the… Expand
National Institutes of Health

Papers overview

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2009
2009
This pilot phase II study was designed to determine the efficacy, toxicities, and biological activity of multiple hepatic… Expand
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2006
2006
More than half of human cancers contain mutations in the tumor suppressor protein p53, most of which accumulate in the DNA… Expand
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Highly Cited
2003
Highly Cited
2003
We identified IFI16 as a BRCA1-associated protein involved in p53-mediated apoptosis. IFI16 contains the Pyrin/PAAD/DAPIN domain… Expand
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2003
2003
OBJECTIVE To evaluate the efficacy and toxicity of recombinant adenovirus p53 injection (SBN-1) in patients with laryngeal cancer… Expand
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2002
2002
Therapeutic replacement of the p53 gene using an adenovirus vector (Ad-p53) may be an effective alternative to conventional… Expand
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Highly Cited
2000
Highly Cited
2000
Maspin has been shown to inhibit tumor cell invasion and metastasis in breast tumor cells. Maspin expression was detected in… Expand
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1999
1999
SCH58500 is an agent for gene therapy of cancer, consisting of a replication-deficient type 5 adenovirus (Ad5) expressing the… Expand
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1997
1997
PURPOSE Overexpressing or restoring the basal levels of tumor suppressor genes in cancer cells can suppress tumorigenicity of… Expand
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1997
1997
We have previously described potent growth-inhibitory effect of a recombinant adenovirus expressing wild type p53 (AdWTp53) in… Expand
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Highly Cited
1996
Highly Cited
1996
Wild-type p53 is involved in several aspects of cell cycle control and suppression of transformation, inducing either apoptosis… Expand
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