Ad5CMV-p53 gene

Known as: Adeno-p53, Adenovirus p53, Ad5CMV-p53 
A replication-defective adenoviral-CMV vector that encodes a wild-type p53 gene. Ad5CMV-p53 induces tumor cells that have been transfected with the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1994-2018
0102019942018

Papers overview

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Highly Cited
2006
Highly Cited
2006
Historically, most studies attribute p53 function to the transactivation of target genes. That p53 can selectively repress genes… (More)
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Highly Cited
2003
Highly Cited
2003
PURPOSE Advances in brain tumor biology indicate that transfer of p53 is an alternative therapy for human gliomas. Consequently… (More)
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Highly Cited
2003
Highly Cited
2003
PURPOSE We designed a prospective single arm Phase II study to evaluate the feasibility and mechanisms of apoptosis induction… (More)
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2000
2000
Induction of wild-type p53 in the ECV-304 bladder carcinoma cell line by infection with a p53 recombinant adenovirus (Ad5CMV-p53… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Preclinical studies in animal models have demonstrated tumor regression following intratumoral administration of an… (More)
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Highly Cited
1998
Highly Cited
1998
PURPOSE Standard therapies of head and neck squamous cell carcinoma (HNSCC) often cause profound morbidity and have not… (More)
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1995
1995
In preparation for a clinical trial of the recombinant p53 adenovirus Ad5CMV-p53 for the treatment of lung cancer, the potential… (More)
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Highly Cited
1995
Highly Cited
1995
Developing gene therapy strategies may allow contemporary medicine to reassess its management of solid malignancies. We have… (More)
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Highly Cited
1995
Highly Cited
1995
We introduced the gene for wild-type human p53 or p21, a critical downstream mediator of p53-induced growth suppression, into a… (More)
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Highly Cited
1994
Highly Cited
1994
Mutations of the p53 gene constitute one of the most frequent genetic alterations in squamous cell carcinoma of the head and neck… (More)
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