Acylphosphatase

Here, we report the application of a computational approach that allows the rational design of enzymes with enhanced… Expand

Protein aggregation is associated with a number of human pathologies including Alzheimer's and Creutzfeldt-Jakob diseases and the… Expand

Protein aggregation and the formation of highly insoluble amyloid structures is associated with a range of debilitating human… Expand

We have systematically studied the effects of 40 single point mutations on the conversion of the denatured form of the… Expand

[NiFe]-hydrogenases require a set of complementary and regulatory proteins for correct folding and maturation processes. One of… Expand

Acylphosphatase can be converted in vitro, by addition of trifluoroethanol (TFE), into amyloid fibrils of the type observed in a… Expand

We have been able to convert a small alpha/beta protein, acylphosphatase, from its soluble and native form into insoluble amyloid… Expand

Muscle acylphosphatase (AcP) is a small protein that folds very slowly with two-state behavior. The conformational stability and… Expand

The folding of a 98 residue protein, muscle acylphosphatase (AcP), has been studied using a variety of techniques including… Expand

Ca2+ transport by cardiac sarcoplasmic reticulum is tightly coupled with the enzymatic activity of Ca2+-dependent ATPase, which… Expand