Acylphosphatase
National Institutes of Health
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Protein aggregation is associated with a number of human pathologies including Alzheimer's and Creutzfeldt-Jakob diseases and the…
We have systematically studied the effects of 40 single point mutations on the conversion of the denatured form of the…
Protein aggregation and the formation of highly insoluble amyloid structures is associated with a range of debilitating human…
Muscle acylphosphatase (AcP) is a small protein that folds very slowly with two-state behavior. The conformational stability and…
We have been able to convert a small alpha/beta protein, acylphosphatase, from its soluble and native form into insoluble amyloid…
Ca2+ transport by cardiac sarcoplasmic reticulum is tightly coupled with the enzymatic activity of Ca2+-dependent ATPase, which…