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Actinium Ac 225 Lintuzumab

Known as: 225Ac-HuM195, Actinium-225-Labeled Humanized Anti-CD33 Monoclonal Antibody HuM195 
A radioimmunoconjugate consisting of the humanized monoclonal antibody lintuzumab conjugated to the alpha-emitting radioisotope actinium Ac 225 with… Expand
National Institutes of Health

Related topics

Related topics

1 relation
NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Genetic signature of prostate cancer mouse models resistant to optimized hK2 targeted α-particle therapy
Significance Molecularly targeted α-therapy is an emerging therapeutic option for prostate cancer patients. We previously… Expand
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2016
2016
Title Engineered recognition of tetravalent zirconium and thorium by chelator-protein systems : Toward flexible radiotherapy and imaging platforms Permalink
Targeted α therapy holds tremendous potential as a cancer treatment: it offers the possibility of delivering a highly cytotoxic… Expand
Review
2014
Review
2014
Novel drugs for older patients with acute myeloid leukemia
Acute myeloid leukemia (AML) is the second most common form of leukemia and the most frequent cause of leukemia-related deaths in… Expand
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2009
2009
Determination of kidney dose distributions using autoradiography and HpGe spectroscopy of kidney after injection of 225Ac-HuM195
 
2008
2008
Sequential Cytarabine and Alpha-Particle Immunotherapy with Bismuth-213 (213Bi)-Labeled-HuM195 (Lintuzumab) for Acute Myeloid Leukemia (AML)
HuM195, a humanized anti-CD33 monoclonal antibody, targets myeloid leukemia cells and has single-agent activity against acute… Expand
Highly Cited
2004
Highly Cited
2004
Pharmacokinetics, dosimetry, and toxicity of the targetable atomic generator, 225Ac-HuM195, in nonhuman primates.
UNLABELLED Short-lived alpha-emitting isotopes individually conjugated to monoclonal antibodies have now reached human use, but… Expand
1995
1995
Interleukin-2 enhancement of cytotoxicity by humanized monoclonal antibody M195 (anti-CD33) in myelogenous leukemia.
Humanized M195 (HuM195) is a genetically engineered, human IgG1 version of the parent M195, a mouse immunoglobulin G2a, anti-CD33… Expand
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1956
1956
ON THE LINEAGE OF ACTINIUM K : Fr$sub 87$$sup 22$$sup 3$
 
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