Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Aconitate Hydratase

Known as: Citrate Hydro Lyase, Hydrolyase, Citrate, Hydro-Lyase, Isocitrate 
An enzyme that catalyzes the reversible hydration of cis-aconitate to yield citrate or isocitrate. It is one of the citric acid cycle enzymes. EC 4.2… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Repression of mitochondrial respiration represents an evolutionarily ancient cellular adaptation to hypoxia and profoundly… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2008
Highly Cited
2008
Parkinson's disease (PD) is a common neurodegenerative disorder thought to be associated with mitochondrial dysfunction. Loss of… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Nitrite (NO2 −) is an intrinsic signaling molecule that is reduced to NO during ischemia and limits apoptosis and cytotoxicity at… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Review
2006
Review
2006
  • T. Rouault
  • Nature chemical biology
  • 2006
  • Corpus ID: 4231191
Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are mammalian proteins that register cytosolic iron concentrations and post… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2005
Highly Cited
2005
To determine the role of reactive oxygen species in mammalian longevity, we generated transgenic mice that overexpress human… Expand
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Mice deficient in CuZn superoxide dismutase (CuZnSOD) showed no overt abnormalities during development and early adulthood, but… Expand
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Mechanisms of mitochondrial superoxide formation remain poorly understood despite considerable medical interest in oxidative… Expand
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Friedreich ataxia (FRDA) is a common autosomal recessive degenerative disease (1/50,000 live births) characterized by a… Expand
Is this relevant?
Review
1995
Review
1995
  • I. Fridovich
  • Annual review of biochemistry
  • 1995
  • Corpus ID: 26834871
O2- oxidizes the [4Fe-4S] clusters of dehydratases, such as aconitase, causing-inactivation and release of Fe(II), which may then… Expand
Is this relevant?
Highly Cited
1995
Highly Cited
1995
The Sod2 gene for Mn–superoxide dismutase (MnSOD), an intramitochondrial free radical scavenging enzyme that is the first line of… Expand
Is this relevant?