Aconitate Hydratase

Known as: Citrate Hydro Lyase, Hydrolyase, Citrate, Hydro-Lyase, Isocitrate 
An enzyme that catalyzes the reversible hydration of cis-aconitate to yield citrate or isocitrate. It is one of the citric acid cycle enzymes. EC 4.2… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1938-2017
05010019382016

Papers overview

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Highly Cited
2010
Highly Cited
2010
NAD(P)H oxidases (Noxs) produce O(2)(-) and play an important role in cardiovascular pathophysiology. The Nox4 isoform is… (More)
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Highly Cited
2009
Highly Cited
2009
Repression of mitochondrial respiration represents an evolutionarily ancient cellular adaptation to hypoxia and profoundly… (More)
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Highly Cited
2008
Highly Cited
2008
Parkinson's disease (PD) is a common neurodegenerative disorder thought to be associated with mitochondrial dysfunction. Loss of… (More)
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Highly Cited
2005
Highly Cited
2005
To determine the role of reactive oxygen species in mammalian longevity, we generated transgenic mice that overexpress human… (More)
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Highly Cited
2005
Highly Cited
2005
The mitochondrial theory of aging proposes that reactive oxygen species (ROS) generated inside the cell will lead, with time, to… (More)
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Highly Cited
2004
Highly Cited
2004
Mechanisms of mitochondrial superoxide formation remain poorly understood despite considerable medical interest in oxidative… (More)
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Highly Cited
1997
Highly Cited
1997
Friedreich ataxia (FRDA) is a common autosomal recessive degenerative disease (1/50,000 live births) characterized by a… (More)
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Highly Cited
1995
Highly Cited
1995
The Sod2 gene for Mn–superoxide dismutase (MnSOD), an intramitochondrial free radical scavenging enzyme that is the first line of… (More)
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Highly Cited
1988
Highly Cited
1988
The experiments reported here identify nitric oxide as a molecular effector of activated macrophage induced cytotoxicity… (More)
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Highly Cited
1987
Highly Cited
1987
Previous studies have shown that cytotoxic activated macrophages cause inhibition of DNA synthesis, of mitochondrial respiration… (More)
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