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Acid Anhydride Hydrolases
Known as:
Acid Anhydride Hydrolases [Chemical/Ingredient]
, acid anhydride hydrolase
, Anhydride Hydrolases, Acid
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A group of enzymes that catalyze the hydrolysis of diphosphate bonds in compounds such as nucleoside di- and tri-phosphates, and sulfonyl-containing…
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National Institutes of Health
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Related topics
Related topics
35 relations
Narrower (26)
Actomyosin Adenosinetriphosphatase
Acylphosphatase
Adenosine Triphosphatases
CEL-1 protein, C elegans
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Broader (1)
Hydrolase
In Blood
Phosphoric Monoester Hydrolases
Process of secretion
antagonists & inhibitors
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Development of organophosphate hydrolase activity in a bacterial homolog of human cholinesterase
P. M. Legler
,
Susanne M. Boisvert
,
J. Compton
,
C. Millard
Frontiers in Chemistry
2014
Corpus ID: 14840367
We applied a combination of rational design and directed evolution (DE) to Bacillus subtilis p-nitrobenzyl esterase (pNBE) with…
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Highly Cited
2010
Highly Cited
2010
Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents
B. Geyer
,
Latha S. Kannan
,
+17 authors
T. Mor
Proceedings of the National Academy of Sciences
2010
Corpus ID: 9112378
The concept of using cholinesterase bioscavengers for prophylaxis against organophosphorous nerve agents and pesticides has…
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2000
2000
Expression of biologically active human butyrylcholinesterase in the cabbage looper (Trichoplusia ni)
P. Platteborze
,
C. Broomfield
Biotechnology and applied biochemistry
2000
Corpus ID: 4898104
This investigation examined the utility of three recombinant protein‐expression systems (COS cells, insect cells and insect…
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Highly Cited
1998
Highly Cited
1998
Organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase: synergy results in a somanase.
C. Millard
,
O. Lockridge
,
C. Broomfield
Biochemistry
1998
Corpus ID: 20238260
Organophosphorus acid anhydride (OP) "nerve agents" are rapid, stoichiometric, and essentially irreversible inhibitors of serine…
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Highly Cited
1997
Highly Cited
1997
A single amino acid substitution, Gly117His, confers phosphotriesterase (organophosphorus acid anhydride hydrolase) activity on human butyrylcholinesterase.
O. Lockridge
,
R. M. Blong
,
P. Masson
,
M. Froment
,
C. Millard
,
C. Broomfield
Biochemistry
1997
Corpus ID: 11281018
The G117H mutant of human butyrylcholinesterase (EC 3.1.1.8) was expressed in Chinese hamster ovary cells. Substitution of Gly…
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Highly Cited
1995
Highly Cited
1995
Design and expression of organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase.
C. Millard
,
O. Lockridge
,
C. Broomfield
Biochemistry
1995
Corpus ID: 23879102
Serine esterases and proteases are rapidly and irreversibly inhibited by organophosphorus (OP) nerve agents. To overcome this…
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1993
1993
A purified recombinant organophosphorus acid anhydrase protects mice against soman.
C. Broomfield
Acta Pharmacologica et Toxicologica
1993
Corpus ID: 40785614
1993
1993
A purified recombinant organophosphorus acid anhydrase protects mice against soman.
C. Broomfield
Chemico-Biological Interactions
1993
Corpus ID: 30939232
Since pharmacologic treatments of organophosphorus anticholinesterases (OPs) are nearing their practical limit other types of…
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