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AZD8186

Known as: AZD-8186, PI3Kbeta Inhibitor AZD8186 
An inhibitor of the beta isoform of phosphoinositide-3 kinase (PI3K), with potential antineoplastic activity. Upon administration, PI3Kbeta inhibitor… Expand
National Institutes of Health

Papers overview

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2018
2018
Loss of the tumor suppressor PTEN confers a tumor cell dependency on the PI3Kβ isoform. Achieving maximal inhibition of tumor… Expand
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2017
2017
Purpose: PTEN-null tumors become dependent on the PI3Kβ isoform and can be targeted by molecules such as the selective PI3K… Expand
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2017
2017
2570Background: Loss of PTEN function leads to increased PI3Kβ signalling. AZD8186 (AZD) exhibits significant anti-tumour… Expand
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2016
2016
BackgroundThe phosphatidylinositol 3 kinase (PI3K) signalling pathway is frequently altered in human cancer and a promising… Expand
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2016
2016
Selective phosphoinositide 3-kinase (PI3K)/AKT/mTOR inhibitors are currently under evaluation in clinical studies. To identify… Expand
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Highly Cited
2015
Highly Cited
2015
BACKGROUND The phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/AKT pathway is frequently activated during prostate cancer… Expand
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2015
2015
Several studies have highlighted the dependency of PTEN deficient tumors to PI3Kβ activity and specific inhibition of PI3Kδ has… Expand
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Review
2015
Review
2015
The healthy immune system protects against infection and malignant transformation without causing significant damage to host… Expand
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2014
2014
Loss of PTEN protein results in upregulation of the PI3K/AKT pathway, which appears dependent on the PI3Kβ isoform. Inhibitors of… Expand
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2013
2013
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC AZD8186 is a novel potent small molecule that… Expand
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