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AZD3514
Known as:
Androgen Receptor Downregulator AZD3514
, SARD AZD3514
An orally available selective androgen receptor (AR) downregulator (SARD), with potential antineoplastic activity. Upon oral administration, AZD3514…
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National Institutes of Health
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Related topics
Related topics
4 relations
AR protein, human
Inhibition of Cell Proliferation
Translational Repression
Broader (1)
Pyridazines
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Type I interferon in patients with systemic autoimmune rheumatic disease is associated with haematological abnormalities and specific autoantibody profiles
J. Reynolds
,
T. Briggs
,
+13 authors
I. Bruce
Arthritis Research & Therapy
2019
Corpus ID: 189861890
ObjectivesTo investigate the relationships between interferon alpha (IFNα) and the clinical and serological phenotype of patients…
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2018
2018
Androgen Receptor Inhibitor Enhances the Antitumor Effect of PARP Inhibitor in Breast Cancer Cells by Modulating DNA Damage Response
A. Min
,
H. Jang
,
+7 authors
S. Im
Molecular Cancer Therapeutics
2018
Corpus ID: 52304580
The androgen receptor (AR) is expressed in 60%–70% of breast cancers regardless of estrogen receptor status, and has been…
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2016
2016
Continual reassessment method for dose escalation clinical trials in oncology: a comparison of prior skeleton approaches using AZD3514 data
G. James
,
S. Symeonides
,
J. Marshall
,
J. Young
,
G. Clack
BMC Cancer
2016
Corpus ID: 4534839
BackgroundThe continual reassessment method (CRM) requires an underlying model of the dose-toxicity relationship (“prior skeleton…
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2016
2016
Voie de signalisation des androgènes, altérations génomiques et progression du cancer de la prostate
P. Barthélémy
2016
Corpus ID: 91161427
La voie de signalisation du recepteur des androgenes (RA) reste une cible therapeutique privilegiee dans les cancers de la…
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Review
2015
Review
2015
Battling resistance mechanisms in antihormonal prostate cancer treatment: Novel agents and combinations.
D. D. De Maeseneer
,
C. Van Praet
,
N. Lumen
,
S. Rottey
Urologic oncology
2015
Corpus ID: 13538973
2015
2015
AZD3514, an oral selective androgen receptor down-regulator in patients with castration-resistant prostate cancer – results of two parallel first-in-human phase I studies
A. Omlin
,
R. Jones
,
+22 authors
T. Elliott
Investigational new drugs
2015
Corpus ID: 3185238
SummaryBackground AZD3514 is a first-in-class, orally bio-available, androgen-dependent and -independent androgen receptor…
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Highly Cited
2013
Highly Cited
2013
AZD3514: A Small Molecule That Modulates Androgen Receptor Signaling and Function In Vitro and In Vivo
S. Loddick
,
S. Ross
,
+22 authors
A. Brooks
Molecular Cancer Therapeutics
2013
Corpus ID: 27746177
Continued androgen receptor (AR) expression and signaling is a key driver in castration-resistant prostate cancer (CRPC) after…
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2013
2013
Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer.
R. Bradbury
,
D. Acton
,
+21 authors
J. M. Wood
Bioorganic & Medicinal Chemistry Letters
2013
Corpus ID: 13517593
2013
2013
A first-in-human study of the oral selective androgen receptor down-regulating drug (SARD) AZD3514 in patients with castration-resistant prostate cancer (CRPC).
A. Omlin
,
Robert R Jones
,
+14 authors
T. Elliott
2013
Corpus ID: 78484550
4511 Background: AZD3514 is a first in class, orally bio-available drug that inhibits androgen-dependent and –independent…
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2012
2012
Abstract 3848: Preclinical profile of AZD3514: A small molecule-targeting androgen receptor function with a novel mechanism of action and the potential to treat castration-resistant prostate cancer
S. Loddick
,
R. Bradbury
,
+15 authors
N. Brooks
2012
Corpus ID: 72641875
The androgen receptor (AR), an important molecular target in the aetiology and progression of prostate cancer, has been found…
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