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AZD3514

Known as: Androgen Receptor Downregulator AZD3514, SARD AZD3514 
An orally available selective androgen receptor (AR) downregulator (SARD), with potential antineoplastic activity. Upon oral administration, AZD3514… Expand
National Institutes of Health

Related topics

Related topics

4 relations
AR protein, humanInhibition of Cell ProliferationTranslational Repression

Broader (1)

Pyridazines

Papers overview

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2019
2019
Type I interferon in patients with systemic autoimmune rheumatic disease is associated with haematological abnormalities and specific autoantibody profiles
ObjectivesTo investigate the relationships between interferon alpha (IFNα) and the clinical and serological phenotype of patients… Expand
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2018
2018
Androgen Receptor Inhibitor Enhances the Antitumor Effect of PARP Inhibitor in Breast Cancer Cells by Modulating DNA Damage Response.
The androgen receptor (AR) is expressed in 60%-70% of breast cancers regardless of estrogen receptor status, and has been… Expand
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2016
2016
Continual reassessment method for dose escalation clinical trials in oncology: a comparison of prior skeleton approaches using AZD3514 data
BackgroundThe continual reassessment method (CRM) requires an underlying model of the dose-toxicity relationship (“prior skeleton… Expand
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2016
2016
Clinical pharmacology profile of an oral selective androgen receptor down-regulator, AZD3514: Implications on the design of ongoing castrate-resistant prostate cancer clinical studies
Purpose: To describe the pharmacokinetics (PK) and pharmacodynamics (PD) of AZD3514 and how the design of the first-time-in-human… Expand
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2016
2016
The value of integrating pre-clinical data to predict nausea and vomiting risk in humans as illustrated by AZD3514, a novel androgen receptor modulator.
Nausea and vomiting are components of a complex mechanism that signals food avoidance and protection of the body against the… Expand
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2015
2015
AZD3514, an oral selective androgen receptor down-regulator in patients with castration-resistant prostate cancer – results of two parallel first-in-human phase I studies
SummaryBackground AZD3514 is a first-in-class, orally bio-available, androgen-dependent and -independent androgen receptor… Expand
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2013
2013
AZD3514: a small molecule that modulates androgen receptor signaling and function in vitro and in vivo.
Continued androgen receptor (AR) expression and signaling is a key driver in castration-resistant prostate cancer (CRPC) after… Expand
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2013
2013
Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer.
Removal of the basic piperazine nitrogen atom, introduction of a solubilising end group and partial reduction of the… Expand
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2013
2013
Optimisation of an immunohistochemistry method for the determination of androgen receptor expression levels in circulating tumour cells
BackgroundAZD3514 inhibits and down regulates the androgen receptor (AR) and has undergone clinical trials in prostate cancer. To… Expand
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2012
2012
Abstract 3848: Preclinical profile of AZD3514: A small molecule-targeting androgen receptor function with a novel mechanism of action and the potential to treat castration-resistant prostate cancer
The androgen receptor (AR), an important molecular target in the aetiology and progression of prostate cancer, has been found… Expand
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