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AUY922
Known as:
Hsp90 Inhibitor AUY922
A derivative of 4,5-diarylisoxazole and a third-generation heat shock protein 90 (Hsp90) inhibitor with potential antineoplastic activity. Hsp90…
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National Institutes of Health
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Related topics
Related topics
2 relations
NCIt Antineoplastic Agent Terminology
Positive Regulation of Apoptosis
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
BAG 3-dependent expression of Mcl-1 confers resistance of mutant KRAS colon cancer cells to the HSP 90 inhibitor AUY 922 † Running title : Mcl-1 confers resistance of colon cancer to HSP 90…
Chun-Yan Wang
,
Tang-Guo Su
,
+4 authors
Chen-Jiang Chen
2017
Corpus ID: 207868656
2015
2015
Analysis of the effect of Ruxolitinib, auy922 and Bortezomib on a cell model of MPNS
Sara Ercole
2015
Corpus ID: 68616156
Myeloproliferative disorders (MPD) are acquired clonal hematopoiesis diseases involving the overproduction of pluripotent stem…
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2013
2013
Phase I study of the HSP90 inhibitor AUY922 in combination with capecitabine as treatment for patients with advanced solid tumors.
S. Pant
,
L. Hart
,
+8 authors
H. Burris
2013
Corpus ID: 220685876
475 Background: Heat shock protein 90 (HSP90) is a molecular chaperone involved in the maintenance and function of client…
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2013
2013
Lung Cancer Growth Small Cell - The HSP90 Inhibitor NVP-AUY922 Potently Inhibits Non
E. Garon
,
R. Finn
,
H. Hamidi
2013
Corpus ID: 90130402
Abstract Heat shock protein 90 (HSP90) is involved in protein folding and functions as a chaperone for numerousclientproteins…
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2013
2013
Kinases Essential for Male Fertility Serine / Threonine Kinases , a Family of Stabilize and Activate the Testis-specific Heat Shock Protein 90 Functions to Signal Transduction :
K. Jha
,
Alyssa R. Coleman
,
Lily Wong
,
A. Salicioni
,
Elizabeth Howcroft
,
G. Johnson
2013
Corpus ID: 207856838
2012
2012
A phase I dose-escalation study of the HSP90 inhibitor AUY922 and erlotinib for patients with EGFR-mutant lung cancer with acquired resistance (AR) to EGFR tyrosine kinase inhibitors (EGFR TKIs).
M. Johnson
,
H. Yu
,
+8 authors
Gregory Riely
2012
Corpus ID: 201993647
3083 Background: AUY922 is a highly potent, non-geldanamycin analog, HSP90 inhibitor that degrades mutated EGFR and MET…
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2011
2011
Cancer Therapy : Preclinical Heat Shock Protein 90 Inhibitor Is Synergistic with JAK 2 Inhibitor and Overcomes Resistance to JAK 2-TKI in Human Myeloproliferative Neoplasm Cells
W. Fiskus
,
S. Verstovsek
,
+10 authors
K. Bhalla
2011
Corpus ID: 1331615
Purpose:We determined the activity of hsp90 inhibitor, and/or Janus-activated kinase 2 (JAK2) tyrosine kinase inhibitor (TKI…
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2009
2009
Abstract #5649: Pharmakokinetic/phamacodynamic relationship of the HSP90 inhibitor NVP-AUY922 in human xenografts and patients in a clinical Phase I trial
M. Jensen
,
S. Ide
,
+4 authors
C. García-echeverría
2009
Corpus ID: 79961095
NVP-AUY922 is a synthetic inhibitor of Heat Shock Protein 90 (HSP90) ATPase activity. HSP90 is a ubiquitously expressed molecular…
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2009
2009
Cancer Therapy : Preclinical CUDC-305 , a Novel Synthetic HSP 90 Inhibitor with Unique Pharmacologic Properties for Cancer Therapy
R. Bao
,
C. Lai
,
+13 authors
C. Qian
2009
Corpus ID: 26567831
Purpose:We designed and synthesized CUDC-305, an HSP90 inhibitor of the novel imidazopyridine class. Here, we report its unique…
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2007
2007
NVP-AUY922 / VER-52296: A novel 3,4 diarylisoxazole Hsp90 chaperone inhibitor discovered via structure-based drug design
Paul A. Brough
,
A. Massey
,
+12 authors
L. Wright
2007
Corpus ID: 85879002
B281 Hsp90 is a molecular chaperone currently the focus of significant research interest as a target for small molecule anti…
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