AUY922

Known as: Hsp90 Inhibitor AUY922 
A derivative of 4,5-diarylisoxazole and a third-generation heat shock protein 90 (Hsp90) inhibitor with potential antineoplastic activity. Hsp90… (More)
National Institutes of Health

Papers overview

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2015
2015
The activation of bypass signals, such as MET and AXL, has been identified as a possible mechanism of EGFR-TKI resistance… (More)
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2014
2014
PURPOSE HSP90 chaperones have key client proteins that are involved in all hallmarks of breast cancer growth and progression. The… (More)
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2013
2013
Heat shock protein 90 (HSP90) is involved in protein folding and functions as a chaperone for numerous client proteins, many of… (More)
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2013
2013
HSP90 enables the activation of many client proteins of which the most clinically validated is HER2. NVP-AUY922, a potent HSP90… (More)
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2010
2010
UNLABELLED Angiogenesis is a critical step in tumor development, in which vascular endothelial growth factor (VEGF) is a key… (More)
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2010
2010
The dismal prognosis of glioblastoma (GB) indicates the urgent need for new therapies for these tumors. Heat shock protein 90… (More)
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2010
2010
Background:Heat-shock protein 90 (Hsp90) has a crucial role in both the stabilisation and regulation of various proteins… (More)
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Highly Cited
2008
Highly Cited
2008
We describe the biological properties of NVP-AUY922, a novel resorcinylic isoxazole amide heat shock protein 90 (HSP90) inhibitor… (More)
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Highly Cited
2008
Highly Cited
2008
Heat shock protein 90 (HSP90) is a key component of a multichaperone complex involved in the post-translational folding of a… (More)
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Highly Cited
2007
Highly Cited
2007
We as well as others have recently shown that Hsp90 is overexpressed in multiple myeloma (MM) and critically contributes to… (More)
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