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Heart disease remains the leading cause of death and disability in the Western world. Current therapies aim at treating the… Expand Both the commitment event and the modality of cell death in photodynamic therapy (PDT) remain poorly defined. We report that PDT… Expand Hepatitis C virus (HCV) core, known to be involved in liver carcinogenesis, is processed in the endoplasmic reticulum (ER). We… Expand OBJECTIVE
Heart failure is associated with alterations in contractile parameters and accompanied by abnormalities in… Expand Abstract: Darier disease (DD) is with a frequency of up to 1 in 36,000 a relatively common genodermatosis with autosomal dominant… Expand Progressive deterioration of cardiac contractility is a central feature of congestive heart failure (CHF) in humans. In this… Expand A mouse model carrying a null mutation in one copy of the sarcoplasmic reticulum (SR) Ca2+-ATPase isoform 2 (SERCA2) gene, in… Expand Darier's disease (DD) is an autosomal dominantly inherited skin disorder characterized by loss of adhesion between epidermal… Expand Phospholamban interacts with SERCA2 (sarco/endoplasmic reticulum calcium ATPase isoform 2) but not SERCA3. The use of chimeric… Expand Ca2+ pumps are essential for removing cytosolic Ca2+ either across the plasma membrane (PM) or into internal organelles such as… Expand