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ATOX1 gene

Known as: ATX, YEAST, HOMOLOG OF, 1, HAH1, antioxidant 1 copper chaperone 
National Institutes of Health

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1 relation
ATOX1 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
Unification of the Copper(I) Binding Affinities of the Metallo-chaperones Atx1, Atox1, and Related Proteins
Literature estimates of metal-protein affinities are widely scattered for many systems, as highlighted by the class of metallo… 
Review
2007
Review
2007
Molecular pathogenesis of Wilson and Menkes disease: correlation of mutations with molecular defects and disease phenotypes
The trace metal copper is essential for a variety of biological processes, but extremely toxic when present in excessive amounts… 
Highly Cited
2007
Highly Cited
2007
Cu(I) Binding and Transfer by the N Terminus of the Wilson Disease Protein*
Wilson and Menkes diseases are genetic disorders of copper metabolism caused by mutations in the Wilson (WND) and Menkes (MNK… 
Review
2004
Review
2004
Intracellular copper transport in mammals.
Copper is an essential cofactor for approximately a dozen cuproenzymes in which copper is bound to specific amino acid residues… 
Highly Cited
2004
Highly Cited
2004
The N-terminal Metal-binding Site 2 of the Wilson's Disease Protein Plays a Key Role in the Transfer of Copper from Atox1*
The Wilson's disease protein (WNDP) is a copper-transporting ATPase regulating distribution of copper in the liver. Mutations in… 
Highly Cited
2003
Highly Cited
2003
Essential role for Atox1 in the copper-mediated intracellular trafficking of the Menkes ATPase
The metallochaperone Atox1 directly interacts with the copper-transporting ATPases and plays a critical role in perinatal copper… 
Highly Cited
2002
Highly Cited
2002
Mammalian Copper Chaperone Cox17p Has an Essential Role in Activation of Cytochrome c Oxidase and Embryonic Development
ABSTRACT Cox17p is essential for the assembly of functional cytochrome c oxidase (CCO) and for delivery of copper ions to the… 
Highly Cited
2000
Highly Cited
2000
Structural basis for copper transfer by the metallochaperone for the Menkes/Wilson disease proteins
The Hah1 metallochaperone protein is implicated in copper delivery to the Menkes and Wilson disease proteins. Hah1 and the N… 
Highly Cited
1999
Highly Cited
1999
Interaction of the copper chaperone HAH1 with the Wilson disease protein is essential for copper homeostasis.
The delivery of copper to specific sites within the cell is mediated by distinct intracellular carrier proteins termed copper… 
Highly Cited
1997
Highly Cited
1997
Identification and Functional Expression of HAH1, a Novel Human Gene Involved in Copper Homeostasis*
To search for a mammalian homologue of ATX1, a human liver cDNA library was screened and a cDNA clone was isolated, which encodes… 
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