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ASP015K

National Institutes of Health

Papers overview

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2015
2015
In vitro/in vivo investigations to examine the gender differences in the pharmacokinetics of novel oral Janus kinase (JAK) inhibitor ASP015K and sulfate metabolite M2 in rats
Abstract 1. Although marked gender differences have been reported for the exposure level of the sulfate metabolite M2 of ASP015K… 
2014
2014
OP0149 A Phase 2B Study of an Oral JAK Inhibitor ASP015K Monotherapy in Japanese Patients with Moderate to Severe Rheumatoid Arthritis
Background ASP015K is a novel oral Janus kinase (JAK) inhibitor in development for the treatment of rheumatoid arthritis (RA… 
2013
2013
AB0363 Coadministration of asp015k, a novel janus kinase inhibitor, with methotrexate demonstrates tolerability and lack of pharmacokinetic interactions in patients with rheumatoid arthritis
Background ASP015K is an oral Janus kinase (JAK) inhibitor with selectivity for JAK1/3 in development for treatment of rheumatoid… 
2013
2013
THU0256 Pharmacodynamics of ASP015K, A Novel Janus Kinase Inhibitor, in Healthy Volunteers
Background ASP015K is an oral Janus kinase (JAK) inhibitor with moderate selectivity for JAK3, a key enzyme for interleukin-2 (IL… 
2013
2013
THU0227 Pooled Analysis of Clinical Safety Data for ASP015K, a Novel Jak Inhibitor in Development for Treatment of Autoimmune Diseases
Background Janus kinase (JAK) enzymes play key roles in cytokine signaling and are important in the pathology of autoimmune… 
2013
2013
AB0364 Pharmacokinetics, safety, and tolerability of asp015k, a novel janus kinase inhibitor, in healthy volunteers
Background ASP015K is an oral Janus kinase (JAK) inhibitor of JAK1/3 in development for treatment of autoimmune diseases (eg… 
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