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ASP 8497

Known as: ASP-8497, ASP8497 
 
National Institutes of Health

Papers overview

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2010
2010
Effects of the dipeptidyl peptidase-4 inhibitor ASP8497 on glucose tolerance in animal models of secondary failure
 
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2009
2009
Antihyperglycemic effects of ASP8497 in streptozotocin-nicotinamide induced diabetic rats: comparison with other dipeptidyl peptidase-IV inhibitors.
(2S,4S)-4-Fluoro-1-({[4-methyl-1-(methylsulfonyl)piperidin-4-yl]amino}acetyl)pyrrolidine-2-carbonitrile monofumarate (ASP8497) is… Expand
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2009
2009
Antidiabetic effects of dipeptidyl peptidase-IV inhibitors and sulfonylureas in streptozotocin-nicotinamide-induced mildly diabetic mice.
The present study investigated the antidiabetic effects of the dipeptidyl peptidase (DPP)-IV inhibitors ASP8497 and vildagliptin… Expand
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2009
2009
Effects of the combination of dipeptidyl peptidase-IV inhibitor ASP8497 and antidiabetic drugs in streptozotocin-nicotinamide-induced mildly diabetic mice.
Several combination therapies have been investigated in an effort to achieve and maintain glycemic control in patients with type… Expand
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2009
2009
Evaluation of the Antidiabetic Effects of Dipeptidyl Peptidase-IV Inhibitor ASP8497 in Streptozotocin-Nicotinamide-Induced Mildly Diabetic Mice
Gastrointestinal hormone glucagon-like peptide-1 (GLP-1) has a potent glucose-dependent insulinotropic effect and is rapidly… Expand
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2009
2009
Effects of the dipeptidyl peptidase-IV inhibitor ASP8497 on glucose tolerance in animal models of secondary failure.
UNLABELLED Sulfonylureas promote insulin secretion and potently lower blood glucose levels, however, they induce hypoglycemia and… Expand
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2008
2008
Chronic inhibition of dipeptidyl peptidase-IV with ASP8497 improved the HbA1c level, glucose intolerance, and lipid parameter level in streptozotocin–nicotinamide-induced diabetic mice
Dipeptidyl peptidase-IV (DPP-IV) is the primary inactivator of glucoregulatory incretin hormones, and DPP-IV inhibitors are… Expand
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2008
2008
Pharmacological profile of ASP8497, a novel, selective, and competitive dipeptidyl peptidase-IV inhibitor, in vitro and in vivo
Dipeptidyl peptidase (DPP)-IV is involved in the inactivation of glucagon-like peptide-1 (GLP-1), a potent insulinotropic peptide… Expand
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2008
2008
ASP8497 is a novel selective and competitive dipeptidyl peptidase-IV inhibitor with antihyperglycemic activity.
Dipeptidyl peptidase (DPP)-IV inhibitors are expected to become a useful new class of antidiabetic agent. The aim of the present… Expand
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