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ASP 8497

Known as: ASP-8497, ASP8497 
 
National Institutes of Health

Papers overview

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2010
2010
Effects of the dipeptidyl peptidase-4 inhibitor ASP8497 on glucose tolerance in animal models of secondary failure
 
2009
2009
Antihyperglycemic effects of ASP8497 in streptozotocin-nicotinamide induced diabetic rats: comparison with other dipeptidyl peptidase-IV inhibitors.
(2S,4S)-4-Fluoro-1-({[4-methyl-1-(methylsulfonyl)piperidin-4-yl]amino}acetyl)pyrrolidine-2-carbonitrile monofumarate (ASP8497) is… Expand
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2009
2009
Effects of the combination of dipeptidyl peptidase-IV inhibitor ASP8497 and antidiabetic drugs in streptozotocin-nicotinamide-induced mildly diabetic mice.
Several combination therapies have been investigated in an effort to achieve and maintain glycemic control in patients with type… Expand
2009
2009
Antidiabetic effects of dipeptidyl peptidase-IV inhibitors and sulfonylureas in streptozotocin-nicotinamide-induced mildly diabetic mice.
The present study investigated the antidiabetic effects of the dipeptidyl peptidase (DPP)-IV inhibitors ASP8497 and vildagliptin… Expand
2009
2009
Evaluation of the Antidiabetic Effects of Dipeptidyl Peptidase-IV Inhibitor ASP8497 in Streptozotocin-Nicotinamide-Induced Mildly Diabetic Mice
Gastrointestinal hormone glucagon-like peptide-1 (GLP-1) has a potent glucose-dependent insulinotropic effect and is rapidly… Expand
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2009
2009
Effects of the dipeptidyl peptidase-IV inhibitor ASP8497 on glucose tolerance in animal models of secondary failure.
UNLABELLED Sulfonylureas promote insulin secretion and potently lower blood glucose levels, however, they induce hypoglycemia and… Expand
2008
2008
Chronic inhibition of dipeptidyl peptidase-IV with ASP8497 improved the HbA1c level, glucose intolerance, and lipid parameter level in streptozotocin–nicotinamide-induced diabetic mice
Dipeptidyl peptidase-IV (DPP-IV) is the primary inactivator of glucoregulatory incretin hormones, and DPP-IV inhibitors are… Expand
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2008
2008
Pharmacological profile of ASP8497, a novel, selective, and competitive dipeptidyl peptidase-IV inhibitor, in vitro and in vivo
Dipeptidyl peptidase (DPP)-IV is involved in the inactivation of glucagon-like peptide-1 (GLP-1), a potent insulinotropic peptide… Expand
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2008
2008
ASP8497 is a novel selective and competitive dipeptidyl peptidase-IV inhibitor with antihyperglycemic activity.
Dipeptidyl peptidase (DPP)-IV inhibitors are expected to become a useful new class of antidiabetic agent. The aim of the present… Expand
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