ASK1 Inhibitor GS-4997

Known as: GS-4997 
An orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2006-2015
01220062015

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
INTRODUCTION Apoptosis signal-regulating kinase 1 (ASK1) is a MAP3K in the JNK and p38 MAPK pathways and responds to various… (More)
Is this relevant?
2015
2015
BACKGROUND Most patients with diabetic kidney disease (DKD) experience disease progression despite receiving standard care… (More)
  • figure 1
  • table 1
  • table 2
Is this relevant?
2015
2015
The effects of GS-4997 (apoptosis signal-regulating kinase 1 inhibitor) on cardiac repolarization were evaluated using a… (More)
Is this relevant?
2009
2009
Previously we have shown that tyrosine 718 of ASK1 when phosphorylated is critical for SOCS1 binding and SOCS1-mediated… (More)
Is this relevant?
Highly Cited
2006
Highly Cited
2006
We have proposed that the age-associated increase of reactive oxygen species (ROS) by electron transport chain (ETC) dysfunction… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2006
2006
The p38 mitogen-activated protein kinase (MAPK) signaling pathway plays an important role in cellular responses to inflammatory… (More)
Is this relevant?