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ASK1 Inhibitor GS-4997

Known as: GS-4997 
An orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic… Expand
National Institutes of Health

Papers overview

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2020
2020
Objective This study was to investigate the mechanism of inflammatory pathology modification induced by ox-LDL in endothelial… Expand
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2020
2020
Apoptosis signal-regulating kinase 1 (ASK1) is a member of mitogen-activated protein kinase kinase kinase (MAP3K) family, which… Expand
2019
2019
Overexpression of ATP-binding cassette (ABC) transporters is one of the most important mechanisms responsible for the development… Expand
2019
2019
Nonalcoholic steatohepatitis represents a significant and rapidly growing unmet medical need. The development of novel therapies… Expand
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2017
2017
Insulin resistance (IR) is an important stress factor in the central nervous system, thereby aggravating neuropathogenesis and… Expand
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2015
2015
The effects of GS‐4997 (apoptosis signal‐regulating kinase 1 inhibitor) on cardiac repolarization were evaluated using a… Expand
2014
2014
Background: Most patients with diabetic kidney disease (DKD) experience disease progression despite receiving standard care… Expand
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2007
2007
s / Neuroscience Research 58S (2007) S1–S244 S107 P1-g0 8 Two types of social buffering differentially attenuates conditioned… Expand
2007
2007
s / Neuroscience Research 58S (2007) S1–S244 S107 P1-g0 8 Two types of social buffering differentially attenuates conditioned… Expand
2007
2007
s / Neuroscience Research 58S (2007) S1–S244 S107 P1-g0 8 Two types of social buffering differentially attenuates conditioned… Expand