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ASK1 Inhibitor GS-4997

Known as: GS-4997 
An orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Ox-LDL Causes Endothelial Cell Injury Through ASK1/NLRP3-Mediated Inflammasome Activation via Endoplasmic Reticulum Stress
Objective This study was to investigate the mechanism of inflammatory pathology modification induced by ox-LDL in endothelial… 
2020
2020
Redundant role of ASK1-mediated p38MAPK activation in human platelet function.
Highly Cited
2019
Highly Cited
2019
Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells.
2019
2019
Development and validation of an in vitro 3D model of NASH with severe fibrotic phenotype.
Nonalcoholic steatohepatitis represents a significant and rapidly growing unmet medical need. The development of novel therapies… 
2017
2017
Melatonin Modulates Neuronal Cell Death Induced by Endoplasmic Reticulum Stress under Insulin Resistance Condition
Insulin resistance (IR) is an important stress factor in the central nervous system, thereby aggravating neuropathogenesis and… 
2015
2015
A Quantitative Framework to Evaluate Proarrhythmic Risk in a First‐in‐Human Study to Support Waiver of a Thorough QT Study
The effects of GS‐4997 (apoptosis signal‐regulating kinase 1 inhibitor) on cardiac repolarization were evaluated using a… 
Highly Cited
2014
Highly Cited
2014
Design of a Phase 2 Clinical Trial of an ASK1 Inhibitor, GS-4997, in Patients with Diabetic Kidney Disease
Background: Most patients with diabetic kidney disease (DKD) experience disease progression despite receiving standard care… 
2007
2007
Two types of social buffering differentially attenuates conditioned fear responses in male rats
2007
2007
Organization of the regions surrounding the medial geniculate nucleus
2007
2007
Behavioral characteristics of ASK1 KO mice
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