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ASK1 Inhibitor GS-4997
Known as:
GS-4997
An orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic…
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National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Ox-LDL Causes Endothelial Cell Injury Through ASK1/NLRP3-Mediated Inflammasome Activation via Endoplasmic Reticulum Stress
L. Hang
,
Yan-Hui Peng
,
R. Xiang
,
Xiangdong Li
,
Zhiliang Li
Drug Design, Development and Therapy
2020
Corpus ID: 212666532
Objective This study was to investigate the mechanism of inflammatory pathology modification induced by ox-LDL in endothelial…
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2020
2020
Redundant role of ASK1-mediated p38MAPK activation in human platelet function.
Kamila M. Śledź
,
S. Moore
,
+5 authors
I. Hers
Cellular Signalling
2020
Corpus ID: 210120492
Highly Cited
2019
Highly Cited
2019
Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells.
N. Ji
,
Yuqi Yang
,
+7 authors
Zhe-Sheng Chen
Cancer Letters
2019
Corpus ID: 52982451
2019
2019
Development and validation of an in vitro 3D model of NASH with severe fibrotic phenotype.
S. Mukherjee
,
L. Zhelnin
,
+5 authors
G. Jarai
American journal of translational research
2019
Corpus ID: 108294499
Nonalcoholic steatohepatitis represents a significant and rapidly growing unmet medical need. The development of novel therapies…
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2017
2017
Melatonin Modulates Neuronal Cell Death Induced by Endoplasmic Reticulum Stress under Insulin Resistance Condition
Juhyun Song
,
O. Y. Kim
Nutrients
2017
Corpus ID: 3999753
Insulin resistance (IR) is an important stress factor in the central nervous system, thereby aggravating neuropathogenesis and…
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2015
2015
A Quantitative Framework to Evaluate Proarrhythmic Risk in a First‐in‐Human Study to Support Waiver of a Thorough QT Study
C. Nelson
,
L. Wang
,
+6 authors
S. Ramanathan
Clinical pharmacology and therapy
2015
Corpus ID: 33386951
The effects of GS‐4997 (apoptosis signal‐regulating kinase 1 inhibitor) on cardiac repolarization were evaluated using a…
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Highly Cited
2014
Highly Cited
2014
Design of a Phase 2 Clinical Trial of an ASK1 Inhibitor, GS-4997, in Patients with Diabetic Kidney Disease
Joseph H. Lin
,
Jenny J Zhang
,
Shao-Lee Lin
,
G. Chertow
Nephron
2014
Corpus ID: 5838411
Background: Most patients with diabetic kidney disease (DKD) experience disease progression despite receiving standard care…
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2007
2007
Two types of social buffering differentially attenuates conditioned fear responses in male rats
Y. Kiyokawa
,
T. Kikusui
,
Y. Takeuchi
,
Y. Mori
Neurosciences research
2007
Corpus ID: 53159854
2007
2007
Organization of the regions surrounding the medial geniculate nucleus
K. Motomura
,
T. Kosaka
Neurosciences research
2007
Corpus ID: 53155790
2007
2007
Behavioral characteristics of ASK1 KO mice
Karen Kumakura
,
H. Nomura
,
T. Noguchi
,
H. Ichijo
,
N. Matsuki
Neurosciences research
2007
Corpus ID: 53153875
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