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ASK1 Inhibitor GS-4997

Known as: GS-4997 
An orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic… Expand
National Institutes of Health

Papers overview

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2019
2019
Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells.
Overexpression of ATP-binding cassette (ABC) transporters is one of the most important mechanisms responsible for the development… Expand
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2019
2019
Development and validation of an in vitro 3D model of NASH with severe fibrotic phenotype.
Nonalcoholic steatohepatitis represents a significant and rapidly growing unmet medical need. The development of novel therapies… Expand
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2017
2017
Melatonin Modulates Neuronal Cell Death Induced by Endoplasmic Reticulum Stress under Insulin Resistance Condition
Insulin resistance (IR) is an important stress factor in the central nervous system, thereby aggravating neuropathogenesis and… Expand
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2015
2015
A Quantitative Framework to Evaluate Proarrhythmic Risk in a First-in-Human Study to Support Waiver of a Thorough QT Study.
The effects of GS-4997 (apoptosis signal-regulating kinase 1 inhibitor) on cardiac repolarization were evaluated using a… Expand
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2014
2014
Design of a Phase 2 Clinical Trial of an ASK1 Inhibitor, GS-4997, in Patients with Diabetic Kidney Disease
Background: Most patients with diabetic kidney disease (DKD) experience disease progression despite receiving standard care… Expand
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2007
2007
Organization of the regions surrounding the medial geniculate nucleus
s / Neuroscience Research 58S (2007) S1–S244 S107 P1-g0 8 Two types of social buffering differentially attenuates conditioned… Expand
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2007
2007
Behavioral characteristics of ASK1 KO mice
s / Neuroscience Research 58S (2007) S1–S244 S107 P1-g0 8 Two types of social buffering differentially attenuates conditioned… Expand
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2007
2007
A possible role for an adaptor protein, X11L/mint2, in risk assessment
s / Neuroscience Research 58S (2007) S1–S244 S107 P1-g0 8 Two types of social buffering differentially attenuates conditioned… Expand
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2007
2007
Two types of social buffering differentially attenuates conditioned fear responses in male rats
s / Neuroscience Research 58S (2007) S1–S244 S107 P1-g0 8 Two types of social buffering differentially attenuates conditioned… Expand
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2007
2007
Chemical property of the neural pathways from the central amygdaloid nucleus to the nucleus retroambiguus via the midbrain periaqueductal gray in the rat
s / Neuroscience Research 58S (2007) S1–S244 S107 P1-g0 8 Two types of social buffering differentially attenuates conditioned… Expand
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