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ASK1 Inhibitor GS-4997

Known as: GS-4997 
An orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic… 
National Institutes of Health

Papers overview

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2020
2020
Objective This study was to investigate the mechanism of inflammatory pathology modification induced by ox-LDL in endothelial… 
2019
2019
Nonalcoholic steatohepatitis represents a significant and rapidly growing unmet medical need. The development of novel therapies… 
2017
2017
Insulin resistance (IR) is an important stress factor in the central nervous system, thereby aggravating neuropathogenesis and… 
2015
2015
The effects of GS‐4997 (apoptosis signal‐regulating kinase 1 inhibitor) on cardiac repolarization were evaluated using a… 
Highly Cited
2014
Highly Cited
2014
Background: Most patients with diabetic kidney disease (DKD) experience disease progression despite receiving standard care…