ASI-222

We compared the abilities of digoxin and aminogalactose digitoxigenin (ASI-222) to bind to, or inhibit, purified dog heart Na+,K… Expand

The effect of therapeutic doses of digitalis in modifying neural activity has been the subject of considerable controversy. In… Expand

The narrow therapeutic range of cardiac glycosides continually challenges chemists to synthetize new derivatives with improved… Expand

We studied the metabolism and cardiac actions of a polar aminocardenolide, 3-beta-O-(4-amino-4,6-dideoxy-beta-D-galactopyranosyl… Expand

Digoxin acts at central neural (CNS) as well as peripheral sites after intravenous administration. In contrast, the analog, 3… Expand

Neural activation by digitalis has been shown to facilitate the development of cardiac arrhythmias and to mediate digitalis… Expand

It has been suggested that central nervous system (CNS) neuroexcitation plays an important role in digitalis-induced cardiac… Expand

Two aminosugar cardiac glycosides, 3-beta-O-(4-amino-4,6-dideoxy-beta-D-galactopyranosyl) digitoxigenin (ASI-222) and its 4… Expand

The effects of ASI-222 HCl and digoxin on cardiac contractile force, dP/dt, heart rate and mean blood pressure in the dog were… Expand

ASI-222,3beta-O-(4-amino-4,6-dideoxy-beta-d-galactopyranosyl) digitoxigenin, is a semi-synthetic cardiac glycoside patterned… Expand