AS 35

Known as: AS-35

National Institutes of Health

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2000

(9-[4-acetyl-3-hydroxy-2-n-propylphenoxy) methyl]-3-(1H-tetrazol-5-yl)-4H-pyrido [1,2-a] pyrimidin-4-one), AS-35, inhibits leukotriene synthesis.

Yoshifumi Hamasaki, M Zaitu, +8 authors Susumu Miyazaki
International journal of immunopharmacology
2000

AS-35, (9-[4-acetyl-3-hydroxy-2-n-propylphenoxy) methyl]-3-(1H-tetrazol-5-yl)-4H-pyrido[1, 2-a] pyrimidin-4-one), was developed… (More)

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1994

[Inhibitory effect of AS-35. a novel antiallergic drug, on chemical mediator release from human eosinophils].

Takahisa Kawashima, Shigeru Nagaki, Atsushi Iwakaji, Ichiro Iwamoto, Sayaka Yoshida, Hiroki Tomioka
Arerugi = [Allergy]
1994

To determine whether AS-35, a new antiallergic drug, inhibits the activation of eosinophils, we examined the effect of AS-35 on… (More)

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1994

Inhibitory effect of aerosol administration of a sulfidopeptide leukotriene antagonist on bronchoconstriction induced by antigen inhalation in guinea pigs.

Takehiko Bando, Maho Fujimura, +4 authors Toshio Matsuda
Arzneimittel-Forschung
1994

The effects of inhalation of the sulfidopeptide leukotriene antagonist AS-35 (9-[(4-Acetyl-3-hydroxy-2-n-propyl-phenoxy)methyl]-3… (More)

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1993

[Effect of AS-35 aerosol on bronchoconstriction induced by specific antigens in macacus rhesus monkeys].

Hiroshi Takata, G. Tamura, Atsuko Shibasaki, Mareki Honma, Takeshi Takishima
Arerugi = [Allergy]
1993

In a previous in vitro study, 9-[(4-acetyl-3-hydroxy-2-n-propylphenoxy) methyl]-3-(1H-tetrazol-5-yl)-4H- pyrido[1,2-a]pyrimidin-4… (More)

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1993

Role of leukotrienes and platelet activating factor in allergic bronchoconstriction and their interactions in guinea pig airway in vivo.

Masumichi Saito, Maho Fujimura, Hideoki Ogawa, Toshio Matsuda
Prostaglandins, leukotrienes, and essential fatty…
1993

Membrane-derived lipid mediators have been considered to play a major role in pathogenesis of bronchial asthma. Recently specific… (More)

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1992

Inhibition of radiolabeled leukotriene-binding by AS-35 in guinea pig lung membrane fraction.

Hiroshi Kasai, Yuki Yanagihara
Japanese journal of pharmacology
1992

The inhibitory effects of 9-[(4-acetyl-3-hydroxy-2-n-propylphenoxy) methyl]-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one… (More)

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1992

Peptide leukotriene antagonistic activity of AS-35, a new antiallergic drug.

Hiroshi Kasai, Takahisa Kawashima, Susumu Omura, Yuki Yanagihara
Japanese journal of pharmacology
1992

The effects of 9-[(4-acetyl-3-hydroxy-2-n-propylphenoxy) methyl]-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one (AS-35), a… (More)

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1992

Effect of AS-35 on agonist-induced contractions and the resting tonus of airway smooth muscles and the in vitro release of chemical mediators from passively sensitized lung fragments from humans and…

S Watanabe-Kohno, Kohichiroh Yasui, +4 authors Kenji Ohata
Japanese journal of pharmacology
1992

Effects of 9-[(4-acetyl-3-hydroxy-2-n-propylphenoxy)methyl]-3-(1H-tetrazol -5-yl)-4H-pyrido[1,2-alpha]pyrimidin-4-one (AS-35) on… (More)

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1991

Interaction of thromboxane A2 and leukotrienes in guinea pig airways in vivo.

Maho Fujimura, Takehiko Bando, Keiichi Mizuhashi, Toshio Matsuda
Prostaglandins
1991

Effects of a thromboxane A2 receptor antagonist (S-1452) on bronchoconstriction induced by inhaled leukotriene C4 and a… (More)

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AS 35

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AS 35

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