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ARQ 197

Known as: (3R,4R)-3-(5,6-Dihydro-4H-pyrrolo(3,2,1-ij)quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione, ARQ-197, ARQ197 
 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Background: Papillary renal cell carcinoma (pRCC) is associated with EGFR expression and activation of MET signaling pathway. A… Expand
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2015
2015
MET targeted therapies are under clinical evaluation for non‐small‐cell lung cancer (NSCLC) patients. Tyrosine kinase inhibitors… Expand
2014
2014
Tivantinib (ARQ197) was first reported as a highly selective inhibitor of c-MET and is currently being investigated in a phase… Expand
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2014
2014
Malignant pleural mesothelioma (MPM) is a lethal disease with scarce therapeutic options, and preclinical studies on new targeted… Expand
Highly Cited
2013
Highly Cited
2013
Purpose: MET, the high-affinity receptor for hepatocyte growth factor, is frequently deregulated in human cancer. Tivantinib… Expand
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2013
2013
We acknowledge the reasoning behind the clinical observations of Dr. Santoro’s team. However, we believe that the authors are… Expand
Review
2011
Review
2011
Hepatocyte growth factor receptor (HGFR), the product of the MET gene, plays an important role in normal cellular function and… Expand
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Highly Cited
2010
Highly Cited
2010
LBA7502 Background: Orally administered ARQ197 is a selective, non-ATP competitive inhibitor of c-MET (MET), a receptor TK… Expand
2010
2010
ARQ-197 is an oral, selective c-Met inhibitor under development by ArQule Inc, in partnership with Daiichi Sankyo Co Ltd and… Expand
2009
2009
3549 Background: ARQ197 (A) is a selective, non-ATP competitive inhibitor of c-Met, a receptor tyrosine kinase implicated in… Expand