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Copious evidence demonstrates the crucial role of Rho GTPase-activating proteins in human malignancies. The downregulation of Rho… Expand Rho GTPase activating protein 15 (ARHGAP15) is a recently identified GTPase activating protein which enhances intrinsic… Expand The small-GTPase Rac1 is a key molecular regulator linking extracellular signals to actin cytoskeleton dynamics. Loss-of-function… Expand Diverticular disease is characterized by pouches (that is, diverticulae) due to weakness in the bowel wall, which can become… Expand Forkhead box P3 (FOXP3) plays a crucial role in the development and function of regulatory T cells and was recently identified as… Expand During brain development, the small GTPases Rac1/Rac3 play key roles in neuronal migration, neuritogenesis, synaptic formation… Expand Background: p21-activated kinases are effectors of Rac1. How Paks are inactivated is not well understood. Results: We found that… Expand In phagocytes, GTPases of the Rac family control crucial antimicrobial functions. The RacGAP ArhGAP15 negatively modulates Rac… Expand African bovine trypanosomiasis caused by Trypanosoma sp., is a major constraint on cattle productivity in sub-Saharan Africa… Expand We have previously described a partial cDNA sequence encoding a RhoGAP protein, GAP25 that is homologous to the recently reported… Expand