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ARHGAP1 gene

Known as: RHOGAP1, p50rhoGAP, GTPase-ACTIVATING PROTEIN, RHO, 1 
 
National Institutes of Health

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Related topics

2 relations
ARHGAP26 generho GTPase-activating protein

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Highly Cited
2009
Highly Cited
2009
Twenty bone mineral density loci identified by large-scale meta-analysis of genome-wide association studies
Bone mineral density (BMD) is a heritable complex trait used in the clinical diagnosis of osteoporosis and the assessment of… Expand
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Highly Cited
2008
Highly Cited
2008
Oncogenic mutations in GNAQ occur early in uveal melanoma.
PURPOSE Early/initiating oncogenic mutations have been identified for many cancers, but such mutations remain unidentified in… Expand
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Highly Cited
2000
Highly Cited
2000
The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development.
Rho GTPases direct actin rearrangements in response to a variety of extracellular signals. P190 RhoGAP (GTPase activating protein… Expand
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Highly Cited
1999
Highly Cited
1999
The crystal structure of rna1p: a new fold for a GTPase-activating protein.
rna1p is the Schizosaccharomyces pombe ortholog of the mammalian GTPase-activating protein (GAP) of Ran. Both proteins are… Expand
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Highly Cited
1998
Highly Cited
1998
Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP.
The isolation of genes involved in cancer development is critical for uncovering the molecular basis of cancer. We report here… Expand
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Highly Cited
1998
Highly Cited
1998
Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP
The Rho-related small GTP-binding protein Cdc42 has a low intrinsic GTPase activity that is significantly enhanced by its… Expand
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Highly Cited
1997
Highly Cited
1997
Structure at 1.65 Å of RhoA and its GTPase-activating protein in complex with a transition-state analogue
Small G proteins of the Rho family, which includes Rho, Rac and Cdc42Hs, regulate phosphorylation pathways that control a range… Expand
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Highly Cited
1997
Highly Cited
1997
Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP
Small G proteins transduce signals from plasma-membrane receptors to control a wide range of cellular functions,. These proteins… Expand
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Highly Cited
1996
Highly Cited
1996
The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases.
We previously described IQGAP1 as a human protein related to a putative Ras GTPase-activating protein (RasGAP) from the fission… Expand
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Highly Cited
1994
Highly Cited
1994
Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases.
GTPase-activating proteins or GAPs play an important role in signal transduction pathways regulated by GTP-binding proteins. In… Expand
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