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ARHGAP1 gene

Known as: RHOGAP1, p50rhoGAP, GTPase-ACTIVATING PROTEIN, RHO, 1 
National Institutes of Health

Related topics

Related topics

2 relations
ARHGAP26 generho GTPase-activating protein

Papers overview

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Highly Cited
2018
Highly Cited
2018
Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A
Significance Prostate cancer is one of most common cancers in men worldwide, and osteoblastic bone metastasis is frequently… Expand
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Highly Cited
2009
Highly Cited
2009
Twenty bone mineral density loci identified by large-scale meta-analysis of genome-wide association studies
Bone mineral density (BMD) is a heritable complex trait used in the clinical diagnosis of osteoporosis and the assessment of… Expand
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Highly Cited
2008
Highly Cited
2008
Oncogenic mutations in GNAQ occur early in uveal melanoma.
PURPOSE Early/initiating oncogenic mutations have been identified for many cancers, but such mutations remain unidentified in… Expand
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Highly Cited
2006
Highly Cited
2006
Tobacco RhoGTPase ACTIVATING PROTEIN1 Spatially Restricts Signaling of RAC/Rop to the Apex of Pollen Tubes
Regulation by Rho-type small GTPases, such as RAC5, is important for the maintenance of polarity in tobacco (Nicotiana tabacum… Expand
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Highly Cited
2000
Highly Cited
2000
The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development.
Rho GTPases direct actin rearrangements in response to a variety of extracellular signals. P190 RhoGAP (GTPase activating protein… Expand
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Highly Cited
1999
Highly Cited
1999
The crystal structure of rna1p: a new fold for a GTPase-activating protein.
rna1p is the Schizosaccharomyces pombe ortholog of the mammalian GTPase-activating protein (GAP) of Ran. Both proteins are… Expand
Highly Cited
1998
Highly Cited
1998
Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP.
The isolation of genes involved in cancer development is critical for uncovering the molecular basis of cancer. We report here… Expand
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Highly Cited
1997
Highly Cited
1997
Structure at 1.65 Å of RhoA and its GTPase-activating protein in complex with a transition-state analogue
Small G proteins of the Rho family, which includes Rho, Rac and Cdc42Hs, regulate phosphorylation pathways that control a range… Expand
Highly Cited
1997
Highly Cited
1997
Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP
Small G proteins transduce signals from plasma-membrane receptors to control a wide range of cellular functions,. These proteins… Expand
Highly Cited
1996
Highly Cited
1996
The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases
We previously described IQGAP1 as a human protein related to a putative Ras GTPase-activating protein (RasGAP) from the fission… Expand
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