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AR 231453
Known as:
AR-231453
, AR231453
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
Oxadiazoles
Pyrimidines
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
GPR119, a Major Enteroendocrine Sensor of Dietary Triglyceride Metabolites Coacting in Synergy With FFA1 (GPR40).
Jeppe H. Ekberg
,
M. Hauge
,
+13 authors
T. Schwartz
Endocrinology
2016
Corpus ID: 25522728
Triglycerides (TGs) are among the most efficacious stimulators of incretin secretion; however, the relative importance of FFA1 (G…
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2016
2016
Biased signaling of lipids and allosteric actions of synthetic molecules for GPR119.
H. A. Hassing
,
S. Fares
,
+6 authors
M. Rosenkilde
Biochemical Pharmacology
2016
Corpus ID: 913812
2014
2014
Structural basis for constitutive activity and agonist‐induced activation of the enteroendocrine fat sensor GPR119
M. S. Engelstoft
,
C. Norn
,
+6 authors
T. Schwartz
British Journal of Pharmacology
2014
Corpus ID: 25610666
GPR119 is a Gαs‐coupled 7TM receptor activated by endogenous lipids such as oleoylethanolamide (OEA) and by the dietary…
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Highly Cited
2011
Highly Cited
2011
Dual elimination of the glucagon and GLP-1 receptors in mice reveals plasticity in the incretin axis.
Safina Ali
,
B. Lamont
,
M. J. Charron
,
D. Drucker
Journal of Clinical Investigation
2011
Corpus ID: 24971609
Disordered glucagon secretion contributes to the symptoms of diabetes, and reduced glucagon action is known to improve glucose…
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Highly Cited
2011
Highly Cited
2011
GPR119 regulates murine glucose homeostasis through incretin receptor-dependent and independent mechanisms.
G. Flock
,
D. Holland
,
Y. Seino
,
D. Drucker
Endocrinology
2011
Corpus ID: 36939792
G protein-coupled receptor 119 (GPR119) was originally identified as a β-cell receptor. However, GPR119 activation also promotes…
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2011
2011
Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control.
G. Semple
,
Albert S. Ren
,
+16 authors
Robert M. Jones
Bioorganic & Medicinal Chemistry Letters
2011
Corpus ID: 22010257
2011
2011
Stimulating β-cell replication and improving islet graft function by AR231453, A GPR119 agonist.
J. Gao
,
L. Tian
,
G. Weng
,
T. O’Brien
,
J. Luo
,
Z. Guo
Transplantation Proceedings
2011
Corpus ID: 36675533
Highly Cited
2010
Highly Cited
2010
N-oleoyldopamine enhances glucose homeostasis through the activation of GPR119.
Z. Chu
,
Chris Carroll
,
+12 authors
J. Leonard
Molecular Endocrinology
2010
Corpus ID: 23845713
G protein-coupled receptor 119 (GPR119) is largely restricted to pancreatic insulin-producing beta-cells and intestinal glucagon…
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Highly Cited
2008
Highly Cited
2008
A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release.
Z. Chu
,
Chris Carroll
,
+11 authors
J. Leonard
Endocrinology
2008
Corpus ID: 25106758
We recently showed that activation of G protein-coupled receptor 119 (GPR119) (also termed glucose dependent insulinotropic…
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Highly Cited
2007
Highly Cited
2007
A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release.
Z. Chu
,
Robert M. Jones
,
+13 authors
J. Leonard
Endocrinology
2007
Corpus ID: 42757640
Pancreatic beta-cell dysfunction is a hallmark event in the pathogenesis of type 2 diabetes. Injectable peptide agonists of the…
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