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AR 231453

Known as: AR-231453, AR231453 
 
National Institutes of Health

Papers overview

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2016
2016
Triglycerides (TGs) are among the most efficacious stimulators of incretin secretion; however, the relative importance of FFA1 (G… Expand
2016
2016
GPR119 is a Gαs-coupled lipid-sensor in the gut, where it mediates release of incretin hormones from the enteroendocrine cells… Expand
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2014
2014
GPR119 is a Gαs‐coupled 7TM receptor activated by endogenous lipids such as oleoylethanolamide (OEA) and by the dietary… Expand
Review
2012
Review
2012
Type 2 diabetes mellitus is associated with a progressive decline in insulinproducing pancreatic β-cells, an increase in hepatic… Expand
Highly Cited
2011
Highly Cited
2011
Disordered glucagon secretion contributes to the symptoms of diabetes, and reduced glucagon action is known to improve glucose… Expand
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Highly Cited
2011
Highly Cited
2011
G protein-coupled receptor 119 (GPR119) was originally identified as a β-cell receptor. However, GPR119 activation also promotes… Expand
2011
2011
We herein outline the design of a new series of agonists of the pancreatic and GI-expressed orphan G-protein coupled receptor… Expand
Highly Cited
2010
Highly Cited
2010
G protein-coupled receptor 119 (GPR119) is largely restricted to pancreatic insulin-producing beta-cells and intestinal glucagon… Expand
Highly Cited
2008
Highly Cited
2008
We recently showed that activation of G protein-coupled receptor 119 (GPR119) (also termed glucose dependent insulinotropic… Expand
Highly Cited
2007
Highly Cited
2007
Pancreatic beta-cell dysfunction is a hallmark event in the pathogenesis of type 2 diabetes. Injectable peptide agonists of the… Expand