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AR 231453

Known as: AR-231453, AR231453 
National Institutes of Health

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2 relations

Broader (2)

OxadiazolesPyrimidines

Papers overview

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Highly Cited
2016
Highly Cited
2016
GPR119, a Major Enteroendocrine Sensor of Dietary Triglyceride Metabolites Coacting in Synergy With FFA1 (GPR40).
Triglycerides (TGs) are among the most efficacious stimulators of incretin secretion; however, the relative importance of FFA1 (G… 
2016
2016
Biased signaling of lipids and allosteric actions of synthetic molecules for GPR119.
2014
2014
Structural basis for constitutive activity and agonist‐induced activation of the enteroendocrine fat sensor GPR119
GPR119 is a Gαs‐coupled 7TM receptor activated by endogenous lipids such as oleoylethanolamide (OEA) and by the dietary… 
Highly Cited
2011
Highly Cited
2011
Dual elimination of the glucagon and GLP-1 receptors in mice reveals plasticity in the incretin axis.
Disordered glucagon secretion contributes to the symptoms of diabetes, and reduced glucagon action is known to improve glucose… 
Highly Cited
2011
Highly Cited
2011
GPR119 regulates murine glucose homeostasis through incretin receptor-dependent and independent mechanisms.
G protein-coupled receptor 119 (GPR119) was originally identified as a β-cell receptor. However, GPR119 activation also promotes… 
2011
2011
Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control.
2011
2011
Stimulating β-cell replication and improving islet graft function by AR231453, A GPR119 agonist.
Highly Cited
2010
Highly Cited
2010
N-oleoyldopamine enhances glucose homeostasis through the activation of GPR119.
G protein-coupled receptor 119 (GPR119) is largely restricted to pancreatic insulin-producing beta-cells and intestinal glucagon… 
Highly Cited
2008
Highly Cited
2008
A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release.
We recently showed that activation of G protein-coupled receptor 119 (GPR119) (also termed glucose dependent insulinotropic… 
Highly Cited
2007
Highly Cited
2007
A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release.
Pancreatic beta-cell dysfunction is a hallmark event in the pathogenesis of type 2 diabetes. Injectable peptide agonists of the… 
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