AMG 458

Known as: AMG-458, AMG458 
 

Topic mentions per year

Topic mentions per year

2008-2012
01220082012

Papers overview

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2012
2012
PURPOSE c-Met is overexpressed in some non-small cell lung cancer (NSCLC) cell lines and tissues. Cell lines with higher levels… (More)
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2012
2012
As part of our effort toward developing an effective therapeutic agent for c-Met-dependent tumors, a pyrazolone-based class II c… (More)
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2010
2010
Understanding the potential for cytochrome P450-mediated drug-drug interactions (DDIs) is a critical step in the drug discovery… (More)
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2009
2009
The development of a robust tablet formulation for a high dose active pharmaceutical ingredient (API) by the trial-and-error… (More)
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2008
2008
A novel series of pyrazolones was recently identifi ed as potent inhibitors of c-Met. Increased selectivity over VEGFR-2 was… (More)
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