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Proper management of severe pain represents one of the most challenging clinical dilemmas. Two equally important goals must be… Expand Abstract Objective. To evaluate the abuse potential of ALO-02, an abuse-deterrent formulation comprising pellets of extended… Expand BackgroundThe efficacy of ALO-02, an abuse-deterrent formulation containing extended-release oxycodone and sequestered naltrexone… Expand Abstract The objective of this multicenter, double-blind, placebo-controlled, randomized withdrawal study was to evaluate the… Expand ALO‐02 is an abuse‐deterrent formulation consisting of capsules filled with pellets of extended‐release oxycodone surrounding… Expand Background and ObjectivesALO-02 capsules, intended to deter abuse, contain pellets of extended-release oxycodone hydrochloride… Expand ALO‐02 is being developed as an abuse‐deterrent formulation of extended‐release oxycodone hydrochloride with naltrexone… Expand Abstract Background: For properly selected patients experiencing chronic pain, extended-release opioid formulations may represent… Expand OBJECTIVE
To evaluate the long-term safety of oxycodone-hydrochloride and sequestered naltrexone-hydrochloride (ALO-02… Expand Background: ALO-02, an opioid formulation intended to deter abuse, comprising capsules filled with pellets of extended-release… Expand