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AJ 9677

Known as: AJ-9677, AJ9677, TAK-677 
National Institutes of Health

Papers overview

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Review
2015
Review
2015
Early investigational β3 adreno-receptor agonists for the management of the overactive bladder syndrome
Introduction: Antimuscarinic drugs form the mainstay of medical treatment for Overactive bladder Syndrome (OAB). With a proven… 
Highly Cited
2011
Highly Cited
2011
Urothelial beta‐3 adrenergic receptors in the rat bladder
To investigate the distribution of beta‐3 adrenergic receptors (β3ARs) in the rat bladder and to examine the contribution of… 
2010
2010
Stabilization by meglumine of an amine compound degraded by formaldehyde in tablets.
2009
2009
Effects of β3-Adrenergic Receptor Activation on Rat Urinary Bladder Hyperactivity Induced by Ovariectomy
Voiding dysfunctions, including increased voiding frequency, urgency, or incontinence, are prevalent in the postmenopausal… 
Highly Cited
2007
Highly Cited
2007
Lack of an effect of a novel beta3-adrenoceptor agonist, TAK-677, on energy metabolism in obese individuals: a double-blind, placebo-controlled randomized study.
OBJECTIVE Our objective was to test the safety and metabolic effects of a novel beta(3)-adrenoreceptor agonist (TAK-677) in… 
2007
2007
Beta3-adrenoceptor agonist AJ-9677 reduces body fat in obese beagles.
2005
2005
Discovery of a novel and potent human and rat beta3-adrenergic receptor agonist, [3-[(2R)-[[(2R)-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1H-indol-7-yloxy]acetic acid.
In search for potent and selective beta3-adrenergic receptor (beta3-AR) agonists as potential drugs for the treatment of type II… 
2005
2005
Chronic effects of AJ-9677 on energy expenditure and energy source utilization in rats.
Review
2002
Review
2002
TAK-677 (Dainippon/Takeda).
TAK-677 is a beta3-adrenergic agonist under development by Dainippon and Takeda for the potential treatment of non-insulin… 
Highly Cited
2001
Highly Cited
2001
Mechanism of amelioration of insulin resistance by beta3-adrenoceptor agonist AJ-9677 in the KK-Ay/Ta diabetic obese mouse model.
The mechanism by which the specific beta3-adrenoceptor agonist AJ-9677 relieves insulin resistance in vivo was investigated by… 
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