AJ 3941

Known as: AJ-3941, Piperazine, 1-(3-fluoro-6,11-dihydrodibenz(b,e)oxepin-11-yl)-4-(3-phenyl-2-propenyl)-, (E)-(+-)-, (Z)-2-butenedioate (1:2)

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1997

1997

Cerebrovascular selectivity and vasospasmolytic action of the novel calcium antagonist (+/-)-(E)-1-(3-fluoro-6, 11-dihydrodibenz[b,e]oxepin-11-yl)-4-(3-phenyl-2-propenyl)-piperazine dimaleate in…

Hiroshi Minato, Masaki Hashizume, Y. Masuda, Buichi Fujitani, Kana Hosoki
Arzneimittel-Forschung
1997

The cerebrovascular selectivity and vasospasmolytic action of AJ-3941 ((+/-)-(E)-1-(3-fluoro-6, 11-dihydrodibenz[b,e]oxepin-11-yl… (More)

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1997

1997

Post-treatment of transient focal cerebral ischemia in rats with the novel cerebrovascular-selective Ca2+ channel antagonist (+/-)-(E)-1-(3-fluoro-6,11-dihydrodibenz[b,e]-oxepine-11-yl)-4-(3-pheny l…

Hiroshi Minato, Ch. Kikuta, Y. Masuda, Buichi Fujitani, Kana Hosoki
Arzneimittel-Forschung
1997

The efficacy of post-ischemic treatment with AJ-3941 ((+/-)-(E)-1-(3-fluoro-6,11-dihydrodibenz[b,e]-oxepine-11-yl )-4-(3-phenyl-2… (More)

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1996

1996

Prevention by the new Ca2+ channel antagonist, AJ-3941, of loss of endothelium-dependent relaxation after subarachnoid hemorrhage in rats.

Hiroshi Minato, Y. Honda, Y. Masuda, Buichi Fujitani, Kana Hosoki
European journal of pharmacology
1996

AJ-3941 ((+/-)-(E)-1-(3-fluoro-6,11-dihydrodibenz[b,e]-oxepine-11-yl ) -4-(3-phenyl-2-propenyl)-piperazine dimaleate; CAS No… (More)

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1996

1996

Effect of (+/-)-(E)-1-(3-fluoro-6,11-dihydrodibenz[b,e]-oxepine-11 -yl)-4-(3-phenyl-2-propenyl)-piperazine dimaleate on cerebral vasospasm and impairment of cerebral circulation in subarachnoid…

Y. Honda, Hiroshi Minato, Y. Masuda, Buichi Fujitani, Kana Hosoki
Arzneimittel-Forschung
1996

A subarachnoid hemorrhage (SAH) model in rats was produced by the injection of homologous blood into the cisterna magna. Effects… (More)

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1996

1996

Protective effect of the novel cerebrovascular-selective calcium antagonist (+/-)-(E)-1-(3-fluoro-6, 11-dihydrodibenz[b,e]-oxepine-11-yl)-4-(3-phenyl-2-propenyl)-piperazine dimaleate on ischemic…

Hiroshi Minato, Y. Honda, Y. Masuda, Buichi Fujitani, Kana Hosoki
Arzneimittel-Forschung
1996

In this study the effect of post-ischemic treatment of AJ-3941 ((+/-)-(E)-1-(3-fluoro-6,11-dihydrodibenz [b,e]-oxepine-11-yl)-4… (More)

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1992

1992

Determination of AJ-3941, a possible agent for the treatment of cerebrovascular disorders, in plasma and brain by means of high-performance liquid chromatography with fluorescence detection.

Masakuni Kurono, K. Yoshida, Shunsuke Naruto
Journal of chromatography
1992

A sensitive and selective high-performance liquid chromatographic method with fluorescence detection is described for the… (More)

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1991

1991

Synthesis and biological activity of 11-[4-(cinnamyl)-1-piperazinyl]- 6,11-dihydrodibenz[b,e]oxepin derivatives, potential agents for the treatment of cerebrovascular disorders.

Mineo Kurokawa, F. Sato, +7 authors J. Matsumoto
Chemical & pharmaceutical bulletin
1991

A series of 11-[4-(cinnamyl)-1-piperazinyl]-6,11-dihydrodibenz[b,e] oxepins and related compounds were synthesized and evaluated… (More)

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