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AGRN gene

Known as: AGRIN, AGRN, agrin proteoglycan 
National Institutes of Health

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Agrin

Papers overview

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Highly Cited
2012
Highly Cited
2012
Biglycan Is an Extracellular MuSK Binding Protein Important for Synapse Stability
The receptor tyrosine kinase MuSK is indispensable for nerve-muscle synapse formation and maintenance. MuSK is necessary for… 
Highly Cited
2002
Highly Cited
2002
Accumulation of heparan sulfate proteoglycans in cerebellar senile plaques
Highly Cited
2001
Highly Cited
2001
Dystroglycan binding to laminin alpha1LG4 module influences epithelial morphogenesis of salivary gland and lung in vitro.
Dystroglycan is a receptor for the basement membrane components laminin-1, -2, perlecan, and agrin. Genetic studies have revealed… 
Highly Cited
2000
Highly Cited
2000
Cloning and Characterization of Muscle-Specific Kinase in Chicken
Muscle-specific kinase (MuSK) is part of the receptor complex that is involved in the agrin-induced formation of the… 
Highly Cited
1999
Highly Cited
1999
Constitutively Active MuSK Is Clustered in the Absence of Agrin and Induces Ectopic Postsynaptic-Like Membranes in Skeletal Muscle Fibers
In skeletal muscle fibers, neural agrin can direct the accumulation of acetylcholine receptors (AChR) and transcription of AChR… 
Highly Cited
1998
Highly Cited
1998
Muscle and Neural Isoforms of Agrin Increase Utrophin Expression in Cultured Myotubes via a Transcriptional Regulatory Mechanism*
Duchenne muscular dystrophy is a prevalent X-linked neuromuscular disease for which there is currently no cure. Recently, it was… 
Highly Cited
1998
Highly Cited
1998
Specific Agrin Isoforms Induce cAMP Response Element Binding Protein Phosphorylation in Hippocampal Neurons
The synaptic basal lamina protein agrin is essential for the formation of neuromuscular junctions. Agrin mediates the… 
Highly Cited
1996
Highly Cited
1996
Substrate-bound agrin induces expression of acetylcholine receptor epsilon-subunit gene in cultured mammalian muscle cells.
Expression of the epsilon-subunit gene of the acetylcholine receptor (AChR) by myonuclei located at the neuromuscular junction is… 
Highly Cited
1996
Highly Cited
1996
Agrin binding to alpha-dystroglycan. Domains of agrin necessary to induce acetylcholine receptor clustering are overlapping but not identical to the alpha-dystroglycan-binding region.
The synaptic basal membrane protein agrin initiates the aggregation of acetylcholine receptors at the postsynaptic membrane of… 
Highly Cited
1991
Highly Cited
1991
Agrin mediates cell contact-induced acetylcholine receptor clustering
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