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AG-490

Known as: AG 490, AG490, tyrphostin AG-490 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Nitriles

Papers overview

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Highly Cited
2010
Highly Cited
2010
5-Hydroxy-2-Methyl-1,4-Naphthoquinone, a Vitamin K3 Analogue, Suppresses STAT3 Activation Pathway through Induction of Protein Tyrosine Phosphatase, SHP-1: Potential Role in Chemosensitization
The activation of signal transducers and activators of transcription 3 (STAT3) has been linked with carcinogenesis through… 
Highly Cited
2008
Highly Cited
2008
Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells
Although leptin induces fibrotic activity in hepatic stellate cells (HSCs), the mechanisms are not entirely understood. To… 
Highly Cited
2008
Highly Cited
2008
JAK2-STAT3 signaling pathway mediates thrombin-induced proinflammatory actions of microglia in vitro
Highly Cited
2006
Highly Cited
2006
Interleukin (IL)‐4 and IL‐13 up‐regulate monocyte chemoattractant protein‐1 expression in human bronchial epithelial cells: involvement of p38 mitogen‐activated protein kinase, extracellular signal…
The Th2 cytokines interleukin (IL)‐4 and IL‐13 and chemokine monocyte chemoattractant protein‐1 (MCP‐1) are significantly… 
Highly Cited
2004
Highly Cited
2004
Molecular Mechanisms Involved in the Growth Stimulation of Breast Cancer Cells by Leptin
Obesity is a risk factor for breast cancer in postmenopausal women. Leptin, an adipocyte-derived cytokine, elicits proliferative… 
Highly Cited
2004
Highly Cited
2004
Low molecular weight hyaluronan from stretched lung enhances interleukin-8 expression.
Mechanical ventilation has been shown to cause ventilator-induced lung injury (VILI), probably by overdistending or stretching… 
Highly Cited
2001
Highly Cited
2001
Neuroprotective effects of leptin in vivo and in vitro
The present study explored the efficacy of leptin in protecting against in vivo induction of excitotoxic lesions by the… 
Highly Cited
2000
Highly Cited
2000
Janus Kinase 2-dependent Activation of p38 Mitogen-activated Protein Kinase by Growth Hormone
We demonstrate here that p38 mitogen-activated protein (MAP) kinase is activated in response to cellular stimulation by human GH… 
Highly Cited
1999
Highly Cited
1999
Tyrphostin AG‐490 inhibits cytokine‐mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen‐activated human T cells
Janus kinase 3 (JAK3) is a cytoplasmic tyrosine kinase required for T cell development and activated by cytokines that utilize… 
Highly Cited
1994
Highly Cited
1994
Tyrphostin induced growth inhibition: correlation with effect on p210bcr-abl autokinase activity in K562 chronic myelogenous leukemia.
We have examined a series of tyrosine kinase inhibitors structurally related to erbstatin (tyrphostins) for inhibition of p210bcr… 
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